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ADCYAP1 — NEUROD6

Text-mined interactions from Literome

DiCicco-Bloom et al., Dev Biol 2000 (Second Messenger Systems) : In addition to neurogenesis, PACAP promoted neuronal differentiation , increasing neurite outgrowth 4-fold and enhancing expression of neurotrophin receptors trkC and trkA
Cazillis et al., Eur J Neurosci 2004 : VIP and PACAP induce selective neuronal differentiation of mouse embryonic stem cells
Nielsen et al., Mol Cell Neurosci 2004 : Interestingly, we also demonstrate that the neurotrophic factors NT-3 and CNTF completely block the PACAP induced neuronal differentiation
Hirose et al., Ann N Y Acad Sci 2006 : These results suggest that PACAP inhibits self-renewal but, instead, induces early neuronal differentiation of neural progenitor cells
Shi et al., Mol Cell Biol 2006 : A novel cyclic AMP dependent Epac-Rit signaling pathway contributes to PACAP38 mediated neuronal differentiation ... Loss-of-function analysis demonstrated that Rit makes an important contribution to PACAP38 mediated neuronal differentiation ... Together, these studies identify an unsuspected connection between cAMP and Rit signaling pathways and imply that Rit can function downstream of G ( s ) alpha/cAMP/Epac in a novel signal transduction pathway necessary for PACAP38 mediated neuronal differentiation and CREB signaling
Monaghan et al., J Neurochem 2008 (Neuroblastoma) : PACAP-38 induces neuronal differentiation of human SH-SY5Y neuroblastoma cells via cAMP mediated activation of ERK and p38 MAP kinases
Shi et al., Mol Cell Biol 2008 (MAP Kinase Signaling System) : Together, these observations identify an unsuspected role for Rin in neuronal PACAP signaling and establish a novel Galpha-Src-Rin-HSP27 signal transduction pathway as a critical element in PACAP38 mediated neuronal differentiation signaling
Zhang et al., Cell Signal 2009 (MAP Kinase Signaling System) : These results reveal an important role of caveolae in the signal transduction of PACAP and that GSK3beta is a critical regulator in PACAP induced neuronal differentiation
Shi et al., Mol Biol Cell 2010 : Recently, the Rit GTPase was found to be activated by a novel Galpha/cAMP/exchange protein activated by cyclic AMP ( Epac ) -dependent signaling pathway and required for PACAP dependent cAMP response element binding protein activation and neuronal differentiation ... Together, these observations expand upon the nature of PACR1 mediated transactivation and identify TrkA-Rit signaling as a key contributor to PACAP dependent neuronal differentiation
Lu et al., Proc Natl Acad Sci U S A 1997 : Moreover, the peptide promoted morphological and biochemical differentiation ; PACAP elicited a 2-fold increase in cells bearing neurites and a 30 % increase in neurotrophin trkB receptor expression, indicating that PACAP induced cell cycle withdrawal and promoted neuronal differentiation