◀ Back to SMAD5
SMAD5 — TGFBR2
Pathways - manually collected, often from reviews:
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NCI Pathway Database ALK1 signaling events:
TGFB3/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB3)
→
SMAD1-5-8 (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003
Evidence: mutant phenotype, assay
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NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CK2B complex (TGFBR2-TGFBR1-ACVRL1-CSNK2B-ENG-TGFB1)
→
SMAD1-5-8-active (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CK2B complex (TGFBR2-TGFBR1-ACVRL1-CSNK2B-ENG-TGFB1)
→
SMAD1-5-8 (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1)
→
SMAD1-5-8-active (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1)
→
SMAD1-5-8 (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/PPP1CA complex (TGFBR2-TGFBR1-ACVRL1-PPP1CA-ENG-TGFB1)
→
SMAD1-5-8 (SMAD1/SMAD9/SMAD5)
(modification, inhibits)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, assay
-
WikiPathways TGF-beta Receptor Signaling:
TGFBR1/TGFBR2
→
SMAD9/SMAD1/SMAD3/SMAD2/SMAD5
(mim-binding)
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WikiPathways TGF-beta Receptor Signaling:
TGFBR1/TGFBR2
→
SMAD9/SMAD1/SMAD3/SMAD2/SMAD5
(mim-modification)
Text-mined interactions from Literome
Verschueren et al., J Biol Chem 1999
:
Activation of
transforming growth factor beta receptors causes the phosphorylation and nuclear translocation of
Smad proteins, which then participate in the regulation of expression of target genes
Luo et al., Mol Cell Proteomics 2006
:
Endogenous
transforming growth factor-beta receptor mediated
Smad signaling complexes analyzed by mass spectrometry
Schniewind et al., Oncogene 2007
(Adenocarcinoma...) :
Ectopic expression of dominant negative mutants of the
TGF-beta type II receptor or type I receptor/activin receptor-like kinase 5 (ALK5) in TGF-beta-sensitive pancreatic ductal adenocarcinoma PANC-1 cells
prevented the TGF-beta induced activation of transfected
Smad-responsive reporter genes and growth arrest