Gene interactions and pathways from curated databases and text-mining

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PARP1 — VAV2

Text-mined interactions from Literome

Arthur et al., J Cell Biol 2004 : Overexpressed VAV2 and Tiam1 specifically require Rap1 to promote spreading, even though Rac1 is activated independently of Rap1 ... Rap1 is necessary for the accumulation of VAV2 in membrane protrusions at the cell periphery
Fukuyama et al., Oncogene 2006 : The c-Src catalysed tyrosine phosphorylation was not sufficient for the activation of Vav2 and the c-Src induced activation of Rap1 was additionally necessary for it, although activated Rap1 alone was not sufficient for the activation of non-tyrosine phosphorylated Vav2 ... This effect of Rap1 on Vav2 was mediated by phosphatidylinositol 3-kinase