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ANXA6 — PTEN
Text-mined interactions from Literome
Huang et al., Arterioscler Thromb Vasc Biol 2002
:
PTEN was expressed endogenously in VSMCs, and PTEN overexpression
inhibited PDGF induced phosphorylation of
p70 ( s6k ), Akt, and glycogen synthase kinase-3-alpha and -beta but not ERK1 or -2
Lee et al., Mol Pharmacol 2006
:
Peroxisome proliferator activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via
PTEN mediated
p70 ribosomal S6 kinase-1 inhibition : role for Zf9 dephosphorylation
Steelman et al., Oncogene 2008
(Breast Neoplasms) :
Interference with the lipid phosphatase activity of
PTEN was
sufficient to activate
Akt/mTOR/p70S6K signaling
Chan et al., Cell Biol Int 2009
:
Collectively, these findings suggest that PP2A and
PTEN may be
involved in fine tuning the regulation of
Akt/tuberin/mTOR/p70S6K in PC12 cells by M ( 4 ) mAChR and TrkA, respectively
Takashima et al., J Gastroenterol 2009
:
Expression of
WT-PTEN also
caused decreased activation of Akt,
p70 ( S6K ), and Erk signaling pathways