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IKBKB — IL8

Text-mined interactions from Literome

Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Wang et al., Infect Immun 2001 : These data indicate that micrococci and PGN induce TLR2 dependent activation of the gene for IL-8 and that this activation requires MyD88, IRAK, NIK, IKK , and NF-kappaB and may also utilize TRAF6 and, to a lesser extent, TRAF2
Casola et al., Virology 2002 : Rotavirus infection of HT-29 induced IkappaB kinase (IKK) activation and overexpression of a dominant negative mutant of IKK-beta greatly reduced rotavirus induced IL-8 promoter activation and NF-kappaB-driven transcription, indicating that IKK is involved in rotavirus induced IL-8 gene expression and NF-kappaB activation
Andreakos et al., Blood 2004 : In contrast, in macrophages neither MyD88, Mal/TIRAP, nor I kappa B kinase 2 (IKK2) are required for NF-kappa B activation or tumor necrosis factor alpha (TNF alpha), IL-6, or IL-8 production, although Mal/TIRAP is still involved in the production of interferon beta (IFN beta)
Podolin et al., J Pharmacol Exp Ther 2005 (Arthritis, Experimental...) : In the present study, we demonstrate that a novel, potent ( IC ( 50 ) = 17.9 nM ), and selective inhibitor of human IKK-2 , 2- [ ( aminocarbonyl ) amino ] -5- ( 4-fluorophenyl ) -3-thiophenecarboxamide ( TPCA-1 ), inhibits lipopolysaccharide induced human monocyte production of TNF-alpha, IL-6, and IL-8 with an IC ( 50 ) = 170 to 320 nM
Catley et al., Br J Pharmacol 2005 (Asthma) : Similarly, IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and TNF alpha dependent increases in ICAM-1, IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression, whereas IKK alpha ( KM ) overexpression had little effect on these outputs
Catley et al., Mol Pharmacol 2006 (Pulmonary Disease, Chronic Obstructive) : As observed above, ICAM-1, IL-6, IL-8 , GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors
Lamothe et al., J Biol Chem 2007 : Reconstituting TRAF6-deficent cells with various TRAF6 mutants, we clearly demonstrate the requirement for the TRAF6 RING domain and site-specific auto-ubiquitination of TRAF6 to activate IKK in response to interleukin-1
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38, and IKK inhibitors block TNF-alpha induced IL-8 , IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
Shah et al., Journal of neuroinflammation 2010 : We have also shown that the NF-?B pathway is involved in gp120 mediated IL-8 overexpression as IKK-2 and IKKß inhibitors inhibited IL-8 expression by 63.5 % and 57.5 %, respectively at the mRNA level, and by 67.3 % and 58.6 % at the protein level
Sachse et al., Rhinology 2011 (Nasal Polyps) : IL-8 and GRO-a responses were repressed by IKK-2 inhibitor TPCA-1 in vitro
Du et al., J Interferon Cytokine Res 2012 (Glioma) : IKK inhibitors inhibit glioma cell proliferation, as well as TNF induced RelA ( p65 ) nuclear translocation and NF?B dependent IL8 gene expression
O'Connell et al., J Biol Chem 1998 : Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2 ... Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2