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FST — GDF11
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
GDF11
→
FST
(decreases)
Evidence: follistatin and deacetylase inhibitors follistatin is a secreted protein that interacts with and inhibits the activity of several TGFB family members including GDF11
Text-mined interactions from Literome
Gamer et al., Dev Biol 1999
:
Interestingly, the activin antagonist,
follistatin , but not noggin, an antagonist of BMPs 2 and 4,
inhibited BMP-11 activity on animal caps
Gamer et al., Dev Biol 2001
:
In addition,
GDF11 induced the expression of its own antagonist
follistatin , indicating that the activity of GFD11 may be limited by a negative feedback mechanism