We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to CASP8

CASP8 — CCDC88A

Text-mined interactions from Literome

Vasko et al., DNA repair 2005 : Reduced Ape1 levels also increase caspase-3 activity in the cells, 2-3-fold, 60min after a 1-h exposure to 100 microM H2O2 in the cultures
Unnikrishnan et al., Free Radic Biol Med 2009 : In addition, loss of APE1/Ref-1 increases the apoptotic response to oxidative stress, in which significant increases in GADD45g expression, p53 protein stability, and caspase activity are observed
Cho et al., Mol Cell Neurosci 2010 : Both silencing of APE/Ref-1 by siRNA and inhibition of endonuclease by an antibody significantly increased caspase-3 activity and apoptotic cell death triggered from the early time after exposure to KA
Nho et al., J Ethnopharmacol 2011 : When we measured the affect of APE on intracellular signaling, APE stimulated the apoptotic factors bcl-2, bcl-xl, mcl-1, XIAP, BID, BIK, caspase-3 , caspase-9 and PARP in HepG2 cells
Kim et al., Acta Histochem 2012 (Diabetes Mellitus, Experimental...) : The augmented APE , in association with increased p53, suppressed cleaved caspase-3