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IRS1 — PRL

Text-mined interactions from Literome

Amaral et al., Horm Metab Res 2003 : To determine possible effects of PRL on insulin signaling pathways, fresh islets were incubated with or without the hormone for 5 or 15 min. Immunoprecipitation and immunoblotting with specific antibodies showed that PRL induced a dose dependent IRS-1 and IRS-2 phosphorylation compared to control islets ... PRL induced increase in IRS-1/-2 phosphorylation was accompanied by an increase in the association with and activation of PI 3-kinase
Berlanga et al., J Biol Chem 1997 : Prolactin activates tyrosyl phosphorylation of insulin receptor substrate 1 and phosphatidylinositol-3-OH kinase
Jacob et al., J Biol Chem 1998 : The negative effect of RPTPalpha on insulin activation of the prolactin promoter is not due to reduced phosphorylation or kinase activity of the insulin receptor or to reduced phosphorylation of insulin receptor substrate-1 or Shc
Yamauchi et al., J Biol Chem 1998 : Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1 , -2, and -3, their association with p85 phosphatidylinositol 3-kinase ( PI3-kinase ), and concomitantly PI3-kinase activation via JAK2 kinase ... Taken together, the role of IRS-1 , -2, and -3 in GH and PRL signalings appears to be phosphorylated by JAK2, thereby providing docking sites for p85 PI3-kinase and activating PI3-kinase and its downstream biological effects