◀ Back to HDAC1
HDAC1 — MBD2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MBD2 (MBD2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
CHD4 (CHD4)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
p66 alpha (GATAD2A)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MBD2 (MBD2)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
p66 beta (GATAD2B)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MTA2 (MTA2)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
CHD3 (CHD3)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD/MBD2/PRMT5 Complex complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
PRMT5 Complex complex (PRMT5-WDR77)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD/MBD2/PRMT5 Complex complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
PRMT5 Complex complex (PRMT5-WDR77)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
CHD4 (CHD4)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
p66 alpha (GATAD2A)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
CHD3 (CHD3)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MBD2 (MBD2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
p66 beta (GATAD2B)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MTA2 (MTA2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MBD3 (MBD3)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MBD2 (MBD2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MBD2 (MBD2)
→
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MBD2 (MBD2)
→
NuRD/MBD3/MBD3L2 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-MBD3L2-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MBD3L2 (MBD3L2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
NuRD/MBD3/MBD3L2 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-MBD3L2-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of HDAC1-MBD3-MBD2-MBD2-RBBP7-RBBP4-RCOR1-MTA2-CHD3
Humphrey et al., J Biol Chem 2001
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(physical association, affinity chromatography technology)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(physical association, affinity chromatography technology)
Joshi et al., Molecular systems biology 2013
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(physical association, affinity chromatography technology)
Brackertz et al., J Biol Chem 2002
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(physical association, affinity chromatography technology)
Ng et al., Nat Genet 1999*
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(association, biochemical)
Zhang et al., Genes Dev 1999
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(direct interaction, pull down)
Zhang et al., Genes Dev 1999
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(physical association, affinity chromatography technology)
Feng et al., Genes Dev 2001
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(physical association, affinity chromatography technology)
Humphrey et al., J Biol Chem 2001
-
IRef Biogrid Interaction:
HDAC1
—
MBD2
(physical association, affinity chromatography technology)
Godmann et al., Biol Reprod 2007*
-
MIPS CORUM SNF2h-cohesin-NuRD complex:
SNF2h-cohesin-NuRD complex complex (BAZ1A-CHD3-HDAC1-HDAC2-MBD2-MBD3-MTA1-MTA2-RAD21-RBBP4-RBBP7-SMARCA5-SMC1A-SMC3-STAG1-STAG2)
Hakimi et al., Nature 2002
-
MIPS CORUM MeCP1 complex:
MeCP1 complex complex (CHD4-HDAC1-HDAC2-MBD2-MBD3-MTA2-RBBP4-RBBP7)
Zhang et al., Genes Dev 1999
-
MIPS CORUM HDAC1-associated protein complex:
HDAC1-associated protein complex complex (KDM1A-CHD3-HDAC1-MBD2-MBD3-MTA2-RBBP4-RBBP7-RCOR1)
Humphrey et al., J Biol Chem 2001
-
MIPS CORUM HDAC1-associated core complex cII:
HDAC1-associated core complex cII complex (CHD3-HDAC1-MBD2-MBD3-MTA2-RBBP4-RBBP7-RCOR1-GATAD2A-GATAD2B)
Humphrey et al., J Biol Chem 2001
-
MIPS CORUM MeCP1 complex:
MeCP1 complex complex (CHD4-GATAD2B-HDAC1-HDAC2-MBD2-MBD3-MTA2-RBBP4-RBBP7)
Feng et al., Genes Dev 2001
-
MIPS CORUM MeCP1 complex:
MeCP1 complex complex (CHD4-GATAD2B-HDAC1-HDAC2-MBD2-MBD3-MTA2-RBBP4-RBBP7)
Feng et al., Mol Cell Biol 2002
-
MIPS CORUM LARC complex (LCR-associated remodeling complex):
LARC complex (LCR-associated remodeling complex) complex (ACTB-ACTL6A-ARID1A-CHD4-DPF2-GATAD2B-HDAC1-HDAC2-HNRNPC-MBD2-MBD3-MTA2-RBBP4-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD2-SMARCE1)
Mahajan et al., Proc Natl Acad Sci U S A 2005
-
IRef Corum Interaction:
Complex of 33 proteins
(association, ion exchange chromatography)
Hakimi et al., Nature 2002
-
IRef Corum Interaction:
Complex of 39 proteins
(association, affinity chromatography technology)
Mahajan et al., Proc Natl Acad Sci U S A 2005
-
IRef Corum Interaction:
Complex of MBD2-HDAC2-RBBP4-MTA2-MBD3-RBBP7-HDAC1-CHD4
(association, pull down)
Zhang et al., Genes Dev 1999
-
IRef Corum Interaction:
Complex of 37 proteins
(association, cosedimentation through density gradient)
Feng et al., Genes Dev 2001
-
IRef Corum Interaction:
Complex of 19 proteins
(association, anti tag coimmunoprecipitation)
Humphrey et al., J Biol Chem 2001
-
IRef Corum Interaction:
Complex of 31 proteins
(association, cosedimentation through density gradient)
Humphrey et al., J Biol Chem 2001
-
IRef Hprd Interaction:
Complex of 265 proteins
(in vivo)
Zhang et al., Genes Dev 1999, Humphrey et al., J Biol Chem 2001, Saito et al., J Biol Chem 2002, Zhang et al., Cell 1998, Tong et al., Nature 1998
-
IRef Hprd Interaction:
HDAC1
—
MBD2
(in vivo)
Ng et al., Nat Genet 1999*
-
IRef Hprd Interaction:
HDAC1
—
MBD2
(in vitro)
Ng et al., Nat Genet 1999*
-
IRef Intact Interaction:
Complex of 26 proteins
(association, anti bait coimmunoprecipitation)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Intact Interaction:
Complex of 40 proteins
(association, anti bait coimmunoprecipitation)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Intact Interaction:
Complex of 92 proteins
(association, anti tag coimmunoprecipitation)
Joshi et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 47 proteins
(association, anti tag coimmunoprecipitation)
Joshi et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 14 proteins
(association, anti bait coimmunoprecipitation)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Ophid Interaction:
MBD2
—
HDAC1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Schutyser et al., J Immunol 2000
(Cell Transformation, Neoplastic) :
Although coinduced with monocyte chemotactic protein-1 (MCP-1) and IL-8 by dsRNA, measles virus, and IL-1beta in diploid fibroblasts, leukocytes produced
LARC/MIP-3alpha only in
response to
LPS
Sekimata et al., J Biol Chem 2001
:
This repression is attenuated by an
HDAC inhibitor, trichostatin A, and is completely
dependent on the interaction with
MBD2
Cardoso et al., Dev Biol 2005
:
This study thus demonstrates that in vivo
XNP-1 acts in association with RB, HP1 and the
NuRD complex during development
Yoshikawa et al., Arch Otolaryngol Head Neck Surg 2006
(Cholesteatoma, Middle Ear) :
The messenger RNA expressions of
LARC ( liver and activation regulated chemokine ), GMCSF ( granulocyte-macrophage colony stimulating factor ), epiregulin, ICAM1 ( intercellular adhesion molecule 1 ), and TGFA ( transforming growth factor alpha ) were more strongly
up-regulated by
IL-1alpha and/or IL-1beta in MECF than in SF, suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles ... The messenger RNA expressions of
LARC ( liver and activation regulated chemokine ), GMCSF ( granulocyte-macrophage colony stimulating factor ), epiregulin, ICAM1 ( intercellular adhesion molecule 1 ), and TGFA ( transforming growth factor alpha ) were more strongly
up-regulated by IL-1alpha and/or
IL-1beta in MECF than in SF, suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles
Topark-Ngarm et al., J Biol Chem 2006
(Neuroblastoma) :
Therefore, it seems likely that the
NuRD complex may be
involved in transcriptional repression of
CTIP2 target genes and contribute to the function ( s ) of CTIP2 within a neuronal context
Gopal et al., Cell cycle (Georgetown, Tex.) 2006
(Inflammation) :
The resulting depletion of cellular
HDAC1 levels
lead to a consequent depletion of
HDAC1 associated with the CDKN1A gene promoter and increased expression of its protein product, p21 ( WAF1/CIP1 )