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RARA — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → RARA (transcriptional regulation, unknown)
  Evidence: DNABINDING, PROMACTIVITY, REG
• FastForward regulation: SP1 → RARA (transcriptional regulation, unknown) Sun et al., Mol Endocrinol 1998*
  Evidence: DNABINDING, PROMACTIVITY, REG
• FastForward regulation: SP1 → RARA (transcriptional regulation, increase) Sun et al., Mol Endocrinol 1998*
  Evidence: DNABINDING, PROMACTIVITY, REG
• FastForward regulation: SP1 → RARA (transcriptional regulation, increase) Zou et al., Mol Endocrinol 1999*
  Evidence: DNABINDING, PROMACTIVITY, REG

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: RARA — SP1 Suzuki et al., Blood 1999*
• IRef Bind_translation Interaction: RARA — SP1 (unspecified method) Suzuki et al., Blood 1999*
• IRef Biogrid Interaction: RARA — SP1 (colocalization, imaging technique) Wu et al., J Biol Chem 2009*
• IRef Biogrid Interaction: RARA — SP1 (direct interaction, pull down) Wu et al., J Biol Chem 2009*
• IRef Biogrid Interaction: RARA — SP1 (physical association, affinity chromatography technology) Cheng et al., J Clin Endocrinol Metab 2008*
• IRef Biogrid Interaction: RARA — SP1 (direct interaction, pull down) Suzuki et al., Blood 1999*
• IRef Hprd Interaction: SP1 — RARA (in vivo) Suzuki et al., Blood 1999*
• IRef Hprd Interaction: SP1 — RARA (in vitro) Suzuki et al., Blood 1999*
• IRef Mppi Interaction: RARA — SP1 (two hybrid) Suzuki et al., Blood 1999*
• IRef Mppi Interaction: RARA — SP1 (coimmunoprecipitation) Suzuki et al., Blood 1999*
• IRef Mppi Interaction: RARA — SP1 (copurification) Suzuki et al., Blood 1999*

Text-mined interactions from Literome

Chen et al., Am J Physiol Gastrointest Liver Physiol 2007 : Site mutations and gel shift assays have identified a Sp1 binding GC box motif at -113 to -108 nts upstream from the MRP3 translation start site, where RXRalpha : RARalpha specifically reduced Sp1 binding to this site
Sun et al., Mol Endocrinol 1998 (Adenocarcinoma...) : Estrogen induced retinoic acid receptor alpha 1 gene expression : role of estrogen receptor-Sp1 complex