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CAPN8 — NFKBIA

Text-mined interactions from Literome

Shumway et al., J Biol Chem 1999 : Moreover, the muCaMLD of calpain acts as a competitive inhibitor of calpain dependent IkappaBalpha degradation
Pianetti et al., Oncogene 2001 (Breast Neoplasms...) : Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN ... Inhibitors of calpain , but not the proteasome, blocked IkappaB-alpha degradation
Shen et al., J Immunol 2001 : Phosphorylation by the protein kinase CK2 promotes calpain mediated degradation of IkappaBalpha ... CK2 phosphorylation enhanced mu-calpain mediated degradation of wild-type IkappaBalpha , but not of mutant 3CIkappaBalpha, with S283A, T291A, and T299A mutations in phosphorylation sites within the PEST domain ... These findings demonstrate for the first time that CK2 phosphorylation of serine/threonine residues in the PEST domain promotes calpain mediated degradation of IkappaBalpha and thereby increases basal NF-kappaB levels in IgM ( + ) B cells
Schölzke et al., Eur J Neurosci 2003 : However, inhibition of the glutamate activated Ca2+ dependent protease calpain by calpeptin completely blocked IkappaBalpha degradation and reduced the nuclear translocation of p65
Schaecher et al., Neurochem Res 2004 : Furthermore, calpain inhibition increased IkB alpha levels compared to nonactivated controls ... The results suggest that calpain plays an important role in IkB alpha degradation, a crucial event in T cell activation
Ponnappan et al., Immunity & ageing : I & A 2005 : Constitutive degradation of IkappaBalpha in human T lymphocytes is mediated by calpain
Młynarczuk-Biały et al., Cancer Res 2006 (Melanoma) : Here, we show that cisplatin resistance in MeWo ( cis1 ) is accompanied by a change in the NF-kappaB activation pathway in favor of calpain mediated IkappaBalpha degradation
Cheng et al., Arch Biochem Biophys 2008 : To explore this potential anti-apoptotic mechanism, we inhibited calpain and proteasome activity in oridonin induced L929 cell apoptosis, and discovered that the inducible IkappaBalpha proteolysis was partially blocked by the inhibition of either calpain or proteasome, but completely blocked by the inhibition of both
Chae et al., Blood 2008 (Familial Mediterranean Fever) : The interaction of N-terminal pyrin with IkappaB-alpha induced calpain mediated degradation of IkappaB-alpha , thus potentiating NF-kappaB activation
Hamelet et al., Mol Genet Metab 2009 (Fatty Liver...) : Our results suggest that hyperhomocysteinemia induces calpain mediated I kappaB alpha degradation which is responsible for anti-apoptotic signals in liver
Wei et al., Am J Physiol Cell Physiol 2009 : Instead, calpain inhibitor can block the IkappaBalpha degradation induced by particles
Li et al., J Biol Chem 2010 (Multiple Myeloma) : Proteasome inhibitor PS-341 ( bortezomib ) induces calpain dependent IkappaB(alpha) degradation ... These data together indicate that PS-341 induces a calpain mediated IkappaB(alpha) degradation independent of caspases
Kim et al., Biochem Biophys Res Commun 2010 (Neoplasms) : Interestingly, the combined inhibition of calpain and the proteasome resulted in an increased accumulation of both I-kappaBalpha polymers and I-kappaBalpha , concurrent with an inhibition of NF-kappaB activity in MDA-MB-231 cells
Chen et al., Arch Biochem Biophys 1997 : This suggests that calpain contributes to silica induced I kappa B alpha degradation and NF-kappa B activation but not to LPS induced I kappa B alpha degradation and NF-kappa B activation