◀ Back to NFKBIA

NFKBIA — PRKAA1

Text-mined interactions from Literome

Sag et al., J Immunol 2008 (Inflammation) : In addition, we found that AMPK negatively regulated LPS induced IkappaB-alpha degradation and positively regulated Akt activation, accompanied by inhibition of glycogen synthase kinase beta and activation of CREB
Wang et al., Circ Res 2010 : Analysis of aortic endothelial cells from AMPKalpha2 ( -/- ) mice and human umbilical vein endothelial cells expressing dominant negative AMPK or AMPKalpha2-specific siRNA revealed that loss of AMPK activity increased NAD ( P ) H oxidase subunit expression ( gp91(phox), p47(phox), p67(phox), NOX1 and -4 ), NAD ( P ) H oxidase mediated superoxide production, 26S proteasome activity, IkappaBalpha degradation, and nuclear translocation of NF-kappaB ( p50 and p65 ), whereas AMPK activation by AICAR or overexpression of constitutively active AMPK had the opposite effect
Liu et al., J Biol Chem 2010 : Furthermore, AMPK activation significantly enhanced IkappaBalpha kinase activation, NF-kappaB nuclear translocation, and DNA binding activity of NF-kappaB