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GCHFR — IRF6

Text-mined interactions from Literome

Roy et al., Surgery 1999 : We harvested adherent peritoneal macrophages harvested from wild-type ( WT ), heterozygous c-fos knockout ( Hetero KO ), or homozygous c-fos knockout ( Homo KO ) mice and investigated lipopolysaccharide (LPS) induced IL-12 p70 protein synthesis ( by enzyme linked immunosorbent assay ), IL-12 p35 and IL-12 p40 messenger RNA accumulation ( mRNA ) ( by reverse transcriptase-polymerase chain reaction ), and the transcription rate ( by nuclear runoff )
Maruyama et al., J Immunol 2003 : While IFN-gamma must be present for IL-12 p40 gene induction, the p35 gene is strongly induced by LPS , even in the absence of IFN-gamma, and therefore the induction of the p35 gene is IRF-1 independent
Dahlberg et al., Virology 2006 (Cardiovirus Infections...) : In contrast to overexpressed IRF-1, IRF-5, and IRF-7, which stimulated p35 promoter reporter activity, overexpressed IRF-3 repressed p35 promoter activity in response to TMEV infection, loxoribine, IFN-gamma/LPS , but not IFN-gamma alone
Salkowski et al., Infect Immun 1997 : We compared the ability of LPS and MPL to induce interleukin-10 (IL-10), IL-12 p35 , IL-12 p40, gamma interferon ( IFN-gamma ), glucocorticoid receptor ( GR ), IL-1 receptor antagonist (IL-1ra), and inducible nitric oxide synthase mRNA expression in murine peritoneal macrophages
Aloisi et al., J Immunol 1997 : In purified microglial cultures from neonatal mouse brains, expression of IL-12 p35 and p40 mRNA is induced by LPS and is stimulated maximally by combined IFN-gamma/LPS treatment, as detected by semiquantitative reverse-transcriptase PCR