Imajo et al., Cell Metab 2012
(Fatty Liver...) :
Here, we demonstrate that upregulation of CD14 by leptin mediated signaling is critical to hyperreactivity against endotoxin during NASH progression ... Administering leptin in chow fed mice caused increased hepatic expression of CD14 via STAT3 signaling, resulting in hyperreactivity against low-dose LPS without steatosis
Jaedicke et al., J Leukoc Biol 2013
:
We therefore investigated a possible role for leptin in monocyte TLR and CD14 expression