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ATF4 — CREB1

Pathways - manually collected, often from reviews:

• FastForward regulation: CREB1 → ATF4 (transcriptional regulation, unknown) Huang et al., Nucleic Acids Res 2005*
  Evidence: DNABINDING
• FastForward regulation: CREB1 → ATF4 (transcriptional regulation, unknown) Zhang et al., Proc Natl Acad Sci U S A 2005
  Evidence: DNABINDING

Text-mined interactions from Literome

Schinelli et al., J Neurosci 2001 : By using selective protein kinase inhibitors and expression of dominant negative Rap1 protein, we also found that the Rap1/PKC/ERK dependent pathway induces the phosphorylation of activating transcription factor-1 , CREB, and Elk-1, whereas the p38MAPK dependent pathway only causes CREB phosphorylation
Kajimura et al., J Exp Med 2011 (Bone Resorption) : We show that the sympathetic tone signals in the osteoblasts to inhibit CREB ( cAMP-responsive element binding protein ) phosphorylation and thus decrease osteoblast proliferation and to promote ATF4 phosphorylation and thus increase RANKL ( receptor activator of NF-?B ligand ) expression, which then stimulates osteoclast differentiation
Cho et al., BMC systems biology 2013 : The three key things from the in silico simulation and experimental results are : 1 ) palmitate induces different signaling pathways ( PKR ( double stranded RNA activated protein kinase ), PERK ( PKR-like ER kinase ), PKA ( cyclic AMP ( cAMP ) -dependent protein kinase A ) in a time dependent-manner, 2 ) both ATF4 and CREB1 ( cAMP-responsive element binding protein 1 ) interact with the Atf4 promoter to contribute to a prolonged accumulation of ATF4, and 3 ) CREB1 is involved in ER-stress induced apoptosis upon palmitate treatment, by regulating ATF4 expression and possibly Ca2+ dependent-CaM ( calmodulin ) signaling pathway