Gene interactions and pathways from curated databases and text-mining

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FAS — IL18

Text-mined interactions from Literome

Tsutsui et al., Immunity 1999 (Liver Diseases) : Caspase-1 independent, Fas/Fas ligand mediated IL-18 secretion from macrophages causes acute liver injury in mice
Menon et al., J Assist Reprod Genet 2001 (Fetal Membranes, Premature Rupture) : IL-18 induces Fas expression, whereas FADD is a constitutively expressed gene in human fetal membranes ... IL-18 induced Fas expression in amniochorion ; however, it failed to turn on other genes in the Fas-FasL apoptosis pathway including FasL and caspase 8
Kang et al., Amino Acids 2007 (Uterine Cervical Neoplasms) : Both mitomycin C and cisplatin induced apoptosis in C-33A cells via caspase-8 and -3 processing in a Fas/FasL dependent manner and also suppressed IL-18 expression, while they down-regulated IkappaB expression and up-regulated p65 expression
Uchiyama et al., J Immunol 2013 (Inflammation...) : However, the role of Fas mediated production of proinflammatory cytokines such as IL-18 and IL-1ß in bacterial infection is unclear
Yamada et al., Diabetologia 1996 (Autoimmune Diseases...) : Mouse islet cell lysis mediated by interleukin-1 induced Fas