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PIK3R1 — PLD5

Text-mined interactions from Literome

Farese et al., Experimental biology and medicine (Maywood, N.J.) 2001 : These changes include : ( i ) activation of phosphatidylinositol 3-kinase (PI3K) and production of PIP3 ; ( ii ) PIP3 dependent activation of atypical protein kinase Cs ( PKCs ) ; ( iii ) PIP3 dependent activation of PKB ; ( iv ) PI3K dependent activation of phospholipase D and hydrolysis of phosphatidylcholine with subsequent increases in phosphatidic acid ( PA ) and diacylglycerol ( DAG ) ; ( v ) PI3K independent activation of glycerol-3-phosphate acylytansferase and increases in de novo synthesis of PA and DAG ; and ( vi ) activation of DAG-sensitive PKCs
Lucas et al., Int J Oncol 2002 (Cell Transformation, Neoplastic) : Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1
Imagawa et al., Arch Biochem Biophys 2005 : These findings suggest that NADPH oxidase is activated by CD through a PKC independent signaling pathway in PMNs, and this pathway involves the activation of PLD through PI3-K