Gene interactions and pathways from curated databases and text-mining

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EGF — ITGA2

Text-mined interactions from Literome

Smida Rezgui et al., Int J Cancer 2000 (Calcium Signaling...) : Our results provide evidence that EGF induced up-regulation of alpha 2 beta 1 integrin contributes to the enhancement of cell-cell adhesion, leading to cell aggregate formation, which permits the escape of A431 cells to EGF induced death by alpha 2 beta 1 integrin signaling
Liang et al., J Biol Chem 2001 : Moreover, epidermal growth factor , which induced a transient ( 1 h ) activation of extracellular signal regulated kinase ( ERK ) in MDCK cells, only slightly increased integrin alpha(2) expression and failed to trigger cell scattering
Sawhney et al., J Biol Chem 2002 : We report that EGF induces integrin alpha2 expression, integrin mediated adhesion, and micromotility of HCT116 cells
Yamanaka et al., Exp Cell Res 2003 (Adenocarcinoma...) : The results of an immunoprecipitation study showed that EGF up-regulated the expression of alpha2beta1-integrin in a dose dependent manner ... The results suggest that EGF promotes cell motility and migration and increases the expression of alpha2beta1-integrin , possibly by decreasing FAK phosphorylation
Ning et al., J Biol Chem 2007 (Ovarian Neoplasms) : Inhibition of EGFRvIII catalytic activity reversed the response, suggesting that EGF receptor activation regulates integrin alpha2
Fujii et al., Exp Cell Res 1995 (Carcinoma, Squamous Cell...) : ELISA and immunoprecipitation studies showed that EGF up-regulated the expression of alpha 2 beta 1 integrin collagen receptor in a time- and dose dependent manner by stimulating biosynthesis of alpha 2 subunit, but did not up-regulate those of the alpha 3 beta 1, alpha 5 beta 1, or alpha v beta 3 integrins
Krensel et al., Int J Cancer 1999 (Adenocarcinoma...) : The EGF induced up-regulation of the alpha2beta1 integrin was instrumental in increasing collagen adhesion of A549 but only partly in the case of A431 cells, in which cells the alpha2beta1 integrin may have additional functions besides serving as cell-ECM receptor