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GAB1 — MAPK14
Text-mined interactions from Literome
Cunnick et al., J Biol Chem 2001
:
Thus, physical association of activated SHP2 with
Gab1 is necessary and
sufficient to mediate the ERK
mitogen activated protein kinase activation
Cai et al., J Cell Biol 2002
(MAP Kinase Signaling System) :
Gab1 and SHP-2
promote Ras/MAPK regulation of epidermal growth and differentiation
Chen et al., J Biol Chem 2002
:
Incubation of cells with the specific EGFR inhibitor AG4178 blocked MbetaCD induced phosphorylation of EGFR, SHC, phospholipase C-gamma, and
Gab-1 as well as
MAPK activation
Lamothe et al., Mol Cell Biol 2004
:
We demonstrate that Gab1 is essential for FGF1 stimulation of both PI 3-kinase and the antiapoptotic protein kinase Akt, while FGF1 induced
mitogen activated protein kinase ( MAPK ) stimulation is not
affected by
Gab1 deficiency
Eulenfeld et al., J Cell Sci 2009
:
Instead, additional
MAPK dependent phosphorylation of Ser551 in
Gab1 is crucial for the recruitment of Gab1 to the plasma membrane