Deng et al., International journal of biological sciences 2011
(Melanoma) :
This study suggests miR-137 may act as a tumor suppressor by directly targeting CtBP1 to inhibit epithelial-mesenchymal transition (EMT) and inducing apoptosis of melanoma cells, thus illustrating a functional link between miR-137 and CtBP1 in melanoma development
Zhang et al., Oncol Rep 2013
:
These data suggest a pivotal role of CtBP1 in EMT of HCC, and its potential as a therapeutic target in human disease