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HPD — IL2
Text-mined interactions from Literome
Kori et al., Infection 2000
(Tuberculosis, Pulmonary) :
PPD stimulation
induced a significant rise in
IL-2 levels in Ethiopians with TB as compared to all other groups
Ranjbar et al., J Immunol 2004
(Tuberculosis, Pulmonary) :
Furthermore, these donors displayed a significant increase in CD8 ( + ) T cells and IL-10 levels and lower levels of
IL-2 and TNF-alpha relative to PPD-responsive donors in
response to
PPD stimulation
Inoue et al., J Immunol 1991
(Mycobacterium Infections) :
When purified CD4-CD8- cells in the LN on day 7 after BCG infection were cultured with sonicated BCG lysate, PPD derived from Mycobacterium tuberculosis or recombinant 65 kDa heat shock protein derived from Mycobacterium bovis, the gamma/delta T cells on this stage significantly proliferated and secreted
IL-2 in
response to sonicated BCG lysate and
PPD but not to 65 kDa heat shock protein
Yoshikai et al., Kekkaku 1991
(Mycobacterium Infections) :
The gamma/delta T cells in PEC on day 7 remarkably proliferated and produced gamma IFN and
IL-2 in
response to sonicated BCG or
PPD derived from Mycobacterium tuberculosis but not to 65 kd heat shock protein ( HSP ) derived from M. bovis
Kurasawa et al., Chest 1991
(Pleural Effusion, Malignant...) :
With the cooperation of these accessory cells, pleural fluid T lymphocytes in patients with tuberculous pleurisy showed a significant level of
interleukin 2 (IL-2) activity in the
presence of
PPD
Toossi et al., J Exp Med 1986
(Tuberculosis, Pulmonary) :
Mean
PPD induced
IL-2 activity was 81.2 % lower in patients as compared with healthy tuberculin reactors
Fujiwara et al., J Immunol 1987
:
IL 1 did not overcome the inhibitory action of the U937 factor on
PPD induced
IL 2 production by human blood T lymphocytes
Shiratsuchi et al., Infect Immun 1987
(Tuberculosis, Pulmonary) :
The addition of recombinant IL-2 also had a restorative effect ( up regulation ) in vitro on the partly impaired
PPD induced
IL-2 receptor expression by PBL from the patients with advanced, refractory tuberculosis
Tsuyuguchi et al., Chest 1988
(Mycobacterium avium-intracellulare Infection...) :
Analysis of defective in vitro PPD induced lymphocyte blastogenic responses in these patients revealed that
PPD induced
interleukin 2 (IL-2) production was impaired whereas PPD induced IL-2 responsiveness was normally developed after PPD stimulation
Israel-Biet et al., Am Rev Respir Dis 1987
(Lung Diseases...) :
Furthermore, alveolar lymphocytes were highly sensitized to PPD, as evaluated by their proliferation and their production of
interleukin 2 in the
presence of
PPD
Kasinrerk et al., Immunology 1994
:
By itself, CD25-8D8 could not induce proliferation of washed 5-day PPD activated lymphocytes during reculturing ; instead, growth enhancement by CD25-8D8 was dependent on the presence of
PPD activated culture supernatant or moderate levels of exogenous
IL-2
Yoshizawa et al., Arerugi 1994
(Asthma) :
PPD induced
IL2 responsiveness was also suppressed by the treatment, but the Con A-induced response was not
Sydora et al., Cell Immunol 1993
:
Some TCR gamma delta cells and gamma delta hybridomas have been reported to recognize purified protein derivative (PPD) ; however, none of the IEL hybridomas secreted
IL-2 in
response to
PPD
Qi et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1995
:
Also the in vitro run-off transcription of
IL-2R alpha gene was
affected by
HPD and light
Nakajima et al., Arerugi 1996
(Asthma) :
PPD induced
IL-2 responsiveness was also suppressed by the treatment, but the Con A-induced response was not
Ng et al., Vet Immunol Immunopathol 1997
(Tuberculosis, Bovine) :
At 7 and 20 weeks after inoculation, bovine
PPD induced IFN-gamma and
IL-2 mRNA expression was detected in all animals with tuberculous lesions and in a proportion of the M. bovis inoculated animals with no lesions