Gene interactions and pathways from curated databases and text-mining

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HPD — IL2

Text-mined interactions from Literome

Kori et al., Infection 2000 (Tuberculosis, Pulmonary) : PPD stimulation induced a significant rise in IL-2 levels in Ethiopians with TB as compared to all other groups
Ranjbar et al., J Immunol 2004 (Tuberculosis, Pulmonary) : Furthermore, these donors displayed a significant increase in CD8 ( + ) T cells and IL-10 levels and lower levels of IL-2 and TNF-alpha relative to PPD-responsive donors in response to PPD stimulation
Inoue et al., J Immunol 1991 (Mycobacterium Infections) : When purified CD4-CD8- cells in the LN on day 7 after BCG infection were cultured with sonicated BCG lysate, PPD derived from Mycobacterium tuberculosis or recombinant 65 kDa heat shock protein derived from Mycobacterium bovis, the gamma/delta T cells on this stage significantly proliferated and secreted IL-2 in response to sonicated BCG lysate and PPD but not to 65 kDa heat shock protein
Yoshikai et al., Kekkaku 1991 (Mycobacterium Infections) : The gamma/delta T cells in PEC on day 7 remarkably proliferated and produced gamma IFN and IL-2 in response to sonicated BCG or PPD derived from Mycobacterium tuberculosis but not to 65 kd heat shock protein ( HSP ) derived from M. bovis
Kurasawa et al., Chest 1991 (Pleural Effusion, Malignant...) : With the cooperation of these accessory cells, pleural fluid T lymphocytes in patients with tuberculous pleurisy showed a significant level of interleukin 2 (IL-2) activity in the presence of PPD
Toossi et al., J Exp Med 1986 (Tuberculosis, Pulmonary) : Mean PPD induced IL-2 activity was 81.2 % lower in patients as compared with healthy tuberculin reactors
Fujiwara et al., J Immunol 1987 : IL 1 did not overcome the inhibitory action of the U937 factor on PPD induced IL 2 production by human blood T lymphocytes
Shiratsuchi et al., Infect Immun 1987 (Tuberculosis, Pulmonary) : The addition of recombinant IL-2 also had a restorative effect ( up regulation ) in vitro on the partly impaired PPD induced IL-2 receptor expression by PBL from the patients with advanced, refractory tuberculosis
Tsuyuguchi et al., Chest 1988 (Mycobacterium avium-intracellulare Infection...) : Analysis of defective in vitro PPD induced lymphocyte blastogenic responses in these patients revealed that PPD induced interleukin 2 (IL-2) production was impaired whereas PPD induced IL-2 responsiveness was normally developed after PPD stimulation
Israel-Biet et al., Am Rev Respir Dis 1987 (Lung Diseases...) : Furthermore, alveolar lymphocytes were highly sensitized to PPD, as evaluated by their proliferation and their production of interleukin 2 in the presence of PPD
Kasinrerk et al., Immunology 1994 : By itself, CD25-8D8 could not induce proliferation of washed 5-day PPD activated lymphocytes during reculturing ; instead, growth enhancement by CD25-8D8 was dependent on the presence of PPD activated culture supernatant or moderate levels of exogenous IL-2
Yoshizawa et al., Arerugi 1994 (Asthma) : PPD induced IL2 responsiveness was also suppressed by the treatment, but the Con A-induced response was not
Sydora et al., Cell Immunol 1993 : Some TCR gamma delta cells and gamma delta hybridomas have been reported to recognize purified protein derivative (PPD) ; however, none of the IEL hybridomas secreted IL-2 in response to PPD
Qi et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1995 : Also the in vitro run-off transcription of IL-2R alpha gene was affected by HPD and light
Nakajima et al., Arerugi 1996 (Asthma) : PPD induced IL-2 responsiveness was also suppressed by the treatment, but the Con A-induced response was not
Ng et al., Vet Immunol Immunopathol 1997 (Tuberculosis, Bovine) : At 7 and 20 weeks after inoculation, bovine PPD induced IFN-gamma and IL-2 mRNA expression was detected in all animals with tuberculous lesions and in a proportion of the M. bovis inoculated animals with no lesions