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CCND1 — IFI27
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chou et al., Breast Cancer Res Treat 1999
:
In the great majority of MCF10AD1 clones, accumulation in G1 phase was accompanied by reduced
cyclin D1 and
increased p27KIP1 protein levels
Swarbrick et al., Mol Cell Biol 2000
(Breast Neoplasms) :
In contrast,
cyclin D-Cdk4 was not
inhibited by His ( 6 ) -p27 in vitro or
p27 ( Kip1 ) in vivo
Lazaar et al., J Immunol 2001
:
VCAM-1 ligation activated extracellular signal regulated kinase 2 and
resulted in increased expression of
cyclin D1 , yet there was neither
p27 ( kip1 ) degradation nor an increase in smooth muscle cell DNA synthesis
Muraoka et al., J Cell Biol 2001
:
However, recent evidence about the stabilizing
effect of
p27 on
cyclin D1-Cdk4 complexes suggests that p27 deficiency might recapitulate the hypoplastic mammary phenotype of cyclin D1-deficient animals
Kong et al., Oncogene 2002
:
Collectively, the effects of cyclin D2 overexpression on mammary gland development during pregnancy and involution are attributed to two major factors, altered
p27 ( kip1 ) protein level and
inhibition of
cyclin D1 phosphorylation
Muñoz et al., J Cell Biochem 2003
(Neuroblastoma) :
Data suggest that in proliferating cells, p27 could be sequestered by direct interaction with cyclin D1, thus preventing its inhibitory action on cell cycle Cdks. Studies also indicate that
p27 is functionally active and that its loss of action on Cdks in proliferating cells is
due to its strong association with
cyclin D1
Watanabe et al., Eur J Oral Sci 2004
:
Lower levels of cyclin D1 were detected in the JE of p21/p27 knockout mice, suggesting that p21 and
p27 regulate stability of
cyclin D1 in oral epithelium
Wu et al., Am J Respir Cell Mol Biol 2006
:
CTGF induced HLF proliferation ; enhanced the expression of
cyclin D1 ; phosphorylated extracellular signal regulated kinase ( ERK ) 1/2, phosphoinositide 3-kinase (PI3-K), protein kinase B (PKB), and DNA binding activity of signal transducers and activators of transcription-3 ( STAT3 ) ; and
inhibited expression of
p27 ( kip1 )
Jonason et al., Cell cycle (Georgetown, Tex.) 2007
:
Here, we show that PTEN negatively regulates expression of cyclin D1 and that
cyclin D1 plays a unique role in
p27 proteolysis ... Coexpression of
cyclin D1 , but not cyclin E, is
sufficient to restore
p27 levels in PTEN expressing cells ... Conversely, loss of
cyclin D1 by siRNA
causes p27 accumulation
Hoque et al., Cancer Epidemiol Biomarkers Prev 2008
(Prostatic Neoplasms) :
Both statins suppressed expression of Rb, phosphorylated Rb,
cyclin D1 , cyclin D3, CDK4, and CDK6, but
induced p21 and
p27 expression in prostate cancer cells
Zhou et al., Int J Cancer 2008
(MAP Kinase Signaling System...) :
While LTF treatment downregulated expression of
cyclin D1 and phosphorylation of retinoblastoma protein ( Rb ), expression of p21 and
p27 in 5-8F NPC cells was
enhanced
Larrea et al., Mol Cell Biol 2008
:
Thus, while PKB dependent p27 phosphorylation appears to increase cyclin D1-Cdk4-p27 assembly or stabilize these complexes in vitro,
cyclin D1-Cdk4-p27 activation
requires the tyrosine phosphorylation of
p27
Festuccia et al., Endocr Relat Cancer 2009
(Disease Models, Animal...) :
In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA, Bax, Bak, p21/WAF1, and
p27/KIP1 , and
inhibiting the activation of Akt activity and the expression of
cyclin D1 , Bcl-2, and Bcl-XL
Roy et al., Journal of molecular signaling 2010
:
SFN induced the expression of p21/CIP1 and
p27/KIP1 , and
inhibited the expression of
cyclin D1
Ganapathy et al., PloS one 2010
(Neoplasm Metastasis...) :
In xenografted tumors, resveratrol upregulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and
p27 ( /KIP1 ), and
inhibited the expression of Bcl-2 and
cyclin D1
Lee et al., J Cell Biochem 2011
:
In the cell cycle related proteins, SJSZ glycoprotein ( 50 ?µg/ml ) significantly
enhances the expression of p53, p21, and
p27 , whereas it suppressed the activity of
cyclin D1/CDK4
Kang et al., Apoptosis 2012
:
Cell cycle analysis indicated thioridazine induced the down-regulation of
cyclin D1 , cyclin A and CDK4, and the
induction of p21 and
p27 , a cyclin dependent kinase inhibitor
OuYang et al., Food Chem 2013
(Carcinoma, Hepatocellular) :
The results show that regarding cell cycle related proteins, three types of polysaccharides significantly
enhance the expression of
p27 ( Kip ) in HepG2 and Bel-7404 cells, while suppressing the activity of
cyclin D1/CDK4 and/or cyclin E/CDK2
Han et al., Cell Growth Differ 1996
:
Increased expression of
cyclin D1 in a murine mammary epithelial cell line
induces p27kip1 , inhibits growth, and enhances apoptosis