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KISS1 — RELA
Text-mined interactions from Literome
Yan et al., J Biol Chem 2001
(Neoplasm Invasiveness) :
However,
NF-kappaB binding to the MMP-9 promoter required for expression of this collagenase was
reduced by
KiSS-1 expression
Cho et al., J Cell Biochem 2009
(Breast Neoplasms...) :
However, it is unclear whether
KiSS1 regulates TNFalpha induced
NF-kappaB activation and further tumor cell migration ... Both
KiSS1 overexpression and KP10 ( kisspeptin-10 ) stimulation
inhibited TNFalpha induced
NF-kappaB activity, suppressed TNFalpha induced cell migration and cell attachment to fibronectin in breast cancer cells while KP10 has little effect on cancer cell proliferation ... Therefore, our data demonstrate that
KiSS1 inhibits TNFalpha induced
NF-kappaB activation via downregulation of RhoA activation and suppression of breast cancer cell migration and invasion