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AHR — TGFB1
Text-mined interactions from Literome
Wolff et al., Mol Pharmacol 2001
(Carcinoma...) :
Cell-specific
regulation of human
aryl hydrocarbon receptor expression by
transforming growth factor-beta(1)
Guo et al., Toxicol Appl Pharmacol 2004
:
The RNA expression profiles support a hypothesis that in the wild type, the
AHR represses
Tgfb gene expression and affects the gene expression of several TGF-beta modulating and processing genes
Jeon et al., J Allergy Clin Immunol 2007
(Bronchial Hyperreactivity) :
To evaluate the roles of FGF2 in
airway hyperresponsiveness (AHR) expression
induced by high levels of
TGF-beta1 , TGF-beta1 TG ( + ) mice were bred with FGF2-deficient mice
Peng et al., Toxicology 2008
(Disease Models, Animal...) :
Repression of
Ah receptor and
induction of
transforming growth factor-beta genes in DEN induced mouse liver tumors
Bussmann et al., Biochem Pharmacol 2008
:
It is well documented that expression and function of the
AHR is negatively
regulated by
transforming growth factor-beta ( TGF-beta ) in many cell types
Burchell et al., Am J Physiol Lung Cell Mol Physiol 2009
(Respiratory Hypersensitivity) :
Partial in vivo depletion or adoptive transfer of Treg cells restored or
inhibited AHR , respectively, but did not affect
TGFbeta(1) or Th2 cytokine production
Gramatzki et al., Oncogene 2009
(Brain Neoplasms...) :
Conversely, pharmacological inhibition of AhR using the novel AhR antagonist, CH-223191, or AhR gene silencing using small interfering RNA showed that constitutive
AhR activity positively
controls TGF-beta1 , TGF-beta2 and latent TGF-beta binding protein-1 protein levels in malignant glioma cells
Gandhi et al., Nat Immunol 2010
:
However, activation of
AhR in the
presence of
transforming growth factor-beta1 induced Foxp3 ( + ) iT ( reg ) cells, which suppress responder T cells through the ectonucleoside triphosphate diphosphohydrolase CD39
Döhr et al., Mol Pharmacol 1997
:
Effect of
transforming growth factor-beta1 on expression of
aryl hydrocarbon receptor and genes of Ah gene battery : clues for independent down-regulation in A549 cells ... In the present study, we report that not only TCDD induced expression of CYP1A1 but also basal mRNA expression of CYP1A1, CYP1B1, and
aryl hydrocarbon receptor (AHR) was
down-regulated by
TGF-beta1 in cells not treated with TCDD
Döhr et al., Biochem Biophys Res Commun 1997
(Breast Neoplasms...) :
The
AhR mRNA expression was not
affected by
TGF-beta1
Zaher et al., Mol Pharmacol 1998
:
The
involvement of
aryl hydrocarbon receptor in the activation of
transforming growth factor-beta and apoptosis