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FGFR1 — MYLIP
Text-mined interactions from Literome
Rio-Machin et al., Leukemia 2013
(Multiple Myeloma...) :
We found that target genes of the most differentially expressed miRNAs are directly involved in the pathogenesis of MM ; specifically, the inhibition of
hsa-miR-425 , hsa-miR-152 and hsa-miR-24, which are all downregulated in h-MM,
leads to the overexpression of CCND1, TACC3, MAFB,
FGFR3 and MYC, which are the also the oncogenes upregulated by the most frequent IgH chromosomal translocations occurring in nh-MM. Importantly, we showed that the downregulation of these specific miRNAs and the upregulation of their targets also occur simultaneously in primary cases of h-MM
Kim et al., Nat Med 2013
(Hypertension, Pulmonary...) :
APLN deficiency in these cells led to increased expression of FGF2 and its receptor
FGFR1 as a
consequence of decreased expression of
miR-424 and miR-503, which directly target FGF2 and FGFR1
Wen et al., Tumour Biol 2013
(Stomach Neoplasms) :
miR-133b acts as a tumor suppressor and negatively
regulates FGFR1 in gastric cancer ... In dual-luciferase reporter assay,
miR-133b reduced the luciferase activity of
Luc-FGFR1-wt , and mutation of miR-133b binding sites abolished the inhibitory effect of miR-133b ... In this study, we found that
miR-133b reduced the protein but not the mRNA levels of endogenous
FGFR1
Mor et al., Neurobiol Dis 2013
(Postmortem Changes) :
We further found that
miR-382 directly
regulates the expression of two genes,
FGFR1 and SPRY4, which are downregulated in both the cultured olfactory cells and LCM-OE derived from schizophrenia patients ... We further found that
miR-382 directly
regulates the expression of two genes,
FGFR1 and SPRY4, which are downregulated in both the cultured olfactory cells and LCM-OE derived from schizophrenia patients