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IL12B — IL1A
Text-mined interactions from Literome
Chieppa et al., J Immunol 2003
(Inflammation) :
MUC III ( a partially purified mucin ), biglycan ( a purified complex proteoglycan ), and mannosylated lipoarabinomannan from Mycobacterium tuberculosis affected cytokine production with high IL-10,
IL-1R antagonist, IL-1R type II, and
inhibition of
IL-12
Mpiga et al., Scand J Immunol 2006
(Chlamydia Infections) :
When infected HeLa cells were co-cultured with THP-1 cells, IL-6 and IL-8 secretion was sustained,
IL-1beta expression followed a bell shaped curve and IL-10,
IL-12p70 and TNF-alpha synthesis was down
regulated
Cheng et al., Int Immunopharmacol 2008
:
The production of
IL-1 was
induced by GP at a dose of 10 microg/mL ; but, NO, IL-6 and
IL-12 was significantly induced at 100 microg/mL
Enríquez-de-Salamanca et al., Cytokine 2008
(Conjunctivitis, Allergic...) :
TNF-alpha stimulated secretion of
IL-12p40 was significantly
increased by 30 min ; GM-CSF, MCP-1, IL-6, IL-7, IL-8, and RANTES were significantly increased by 2 h, and IFN-gamma and
IL-1alpha by 24 h
Annunziato et al., Blood 2009
(Autoimmune Diseases) :
While murine Th17 cells develop in response to IL-6,
IL-1 , and transforming growth factor ( TGF ) -beta, human Th17 cells originate from these CD161 ( + ) precursors in
response to IL-1beta and
IL-23 , the need for TGF-beta being controversial
Tomizawa et al., Rheumatology (Oxford) 2010
(Glomerulonephritis...) :
In contrast, the
IL-1alpha level increased, and IL-17 and
IL-12p70 slightly
increased with DSG treatment
Donini et al., Prostate 2012
(Prostatic Neoplasms) :
LNCaP
enhance IL-1ß , IL-23, IL-6, and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases
IL-12 production through NADPH oxidase unrelated mechanisms
Mutamba et al., Eur J Immunol 2012
:
Furthermore,
IL-1F8 stimulated increased CD40 and CD80 expression and IL-18 and
IL-12 p70 production by MDDCs, which induced proliferation of IFN-? producing CD3 ( + ) lymphocytes ( indicative of inflammatory Th1 subsets )
Kim et al., J Immunol 2012
(Disease Models, Animal...) :
PLC activation enhanced the bactericidal activity and hydrogen peroxide production of mouse neutrophils, and it also
enhanced the production of IFN-? and
IL-12 while inhibiting proseptic TNF-a and
IL-1ß production in cecal ligation and puncture mice
Burnham et al., Am J Physiol Lung Cell Mol Physiol 2013
(Alcoholism) :
Cigarette smoking duration was associated with higher IL-1ß ( P = 0.0009 ) but lower VEGF ( P = 0.0007 ) ; cigarette smoking intensity was characterized by higher
IL-1ß and lower VEGF and
diminished IL-12 ( P = 0.0004 )
Grewe et al., J Immunol 1998
:
The expression of both
IL-12 protein and mRNAs for the p35 and p40 IL-12 subunits was strongly induced in all donors by the Th2-like cytokines IL-4 and granulocyte-macrophage CSF and was also moderately
induced by TNF-alpha and
IL-1alpha