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IL20 — IL22

Text-mined interactions from Literome

Fickenscher et al., Trends Immunol 2002 : For example, whereas IL-10 is a well studied pleiotropic immunosuppressive and immunostimulatory cytokine, IL-22/IL-TIF mediates acute-phase response signals in hepatocytes and IL-20 induces the hyperproliferation of keratinocytes, which has been proposed as a pathogenic mechanism of psoriasis
Conti et al., Immunol Lett 2003 : IL-20 induces cheratin proliferation and Stat-3 signal transduction pathway, while IL-22 induces acute-phase production by hepatocytes and neonatal lethality with skin abnormalities reminiscent of psoriasic lesions in humans
Wolk et al., Eur J Immunol 2009 (Psoriasis) : The Th17 cytokine IL-22 induces IL-20 production in keratinocytes : a novel immunological cascade with potential relevance in psoriasis ... Furthermore, IL-17A and TNF-alpha individually strengthened the IL-22 induced IL-20 production
Marijnissen et al., Arthritis Rheum 2011 (Arthritis, Experimental...) : Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation