◀ Back to IGF1
IGF1 — MAP2K1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Dunn et al., Cancer Res 2001
(Breast Neoplasms...) :
In summary, we conclude that
IGF-I requires both phosphatidylinositol 3-kinase and
mitogen activated protein kinase kinase dependent pathways to optimally induce uPA expression
Mehrhof et al., Circulation 2001
:
IGF-I also induced phosphorylation of cAMP response element binding protein ( CREB ) in a PI3K- and
MEK1 dependent manner
Shibata et al., Life Sci 2009
:
IGF-1 induced phosphorylation of extracellular related kinase (ERK)1/2,
MAP or ERK kinase (MEK)1/2 , and Akt, expression of cyclin D1, and MC proliferation in cultured human MCs ... Fluvastatin or PD98059, an MEK1 inhibitor, completely abolished
IGF-1 induced
MEK1/2 and ERK1/2 phosphorylation and MC proliferation, whereas inhibition of Akt had no effect on MC proliferation ... Mevalonic acid prevented fluvastatin inhibition of
IGF-1 induced
MEK1/2 and ERK1/2 phosphorylation, cyclin D1 expression, and MC proliferation
Jiang et al., Am J Physiol Endocrinol Metab 2011
(MAP Kinase Signaling System) :
In carp pituitary cells,
IGF-I and -II could
induce rapid phosphorylation of IGF-I receptor,
MEK1/2 , ERK1/2, MKK3/6, and p38 MAPK ; and SLa and SLß secretion, protein production, and mRNA expression caused by IGF-I and -II stimulation were negated by inactivating MEK1/2 and p38 MAPK