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GRAP2 — SPHK1
Text-mined interactions from Literome
Johnstone et al., Placenta 2005
:
Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase, Akt, ERK1/2 or
p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % )
inhibited the EGF stimulated increase in
SPHK-1 activity
Schenten et al., J Leukoc Biol 2011
:
These results define a pathway leading to NOX2 activation, in which
p38 MAPK mediated S100A8/A9 translocation is
regulated by Ca ( 2+ ) store depletion dependent
SphK activation