Gene interactions and pathways from curated databases and text-mining

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GRAP2 — SPHK1

Text-mined interactions from Literome

Johnstone et al., Placenta 2005 : Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase, Akt, ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the EGF stimulated increase in SPHK-1 activity
Schenten et al., J Leukoc Biol 2011 : These results define a pathway leading to NOX2 activation, in which p38 MAPK mediated S100A8/A9 translocation is regulated by Ca ( 2+ ) store depletion dependent SphK activation