Gene interactions and pathways from curated databases and text-mining

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BCL2 — IL8

Text-mined interactions from Literome

Nör et al., Cancer Res 2001 (Carcinoma, Squamous Cell...) : Transfection of antisense Bcl-2 into HDMECs blocked VEGF mediated induction of IL-8
Zhou et al., Hepatobiliary Pancreat Dis Int 2013 (Adenocarcinoma...) : The purpose of this study was to investigate the roles of the pro-apoptotic TRAIL receptors, TRAIL-R1 and TRAIL-R2, as well as Bcl-xL and TRAF2 in TRAIL induced expression of the pro-inflammatory cytokine IL-8 and the invasion promoting protein urokinase ( uPA ) in pancreatic ductal adenocarcinoma ( PDAC ) cells ... Overexpression of TRAF2 or Bcl-xL strongly increased TRAIL mediated upregulation of uPA and IL-8
Wakisaka et al., Clin Exp Immunol 1998 (Arthritis, Rheumatoid) : Anti-Fas MoAb induced apoptosis of RA synovial cells in vitro, and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta, but not IL-6 or IL-8 , inhibited the anti-Fas induced apoptosis accompanying up-regulation of Bcl-2 protein expression and reduced expression of CPP32 and ICH-1L. Immunohistochemical study revealed that CPP32 and ICH-1L were expressed weakly in the RA synovial lining cells compared with osteoarthritis ( OA ) synovial lining cells