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MSX2 — RUNX2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MSX2 — RUNX2 (physical association, affinity chromatography technology) Shirakabe et al., Genes Cells 2001*
• IRef Hprd Interaction: RUNX2 — MSX2 (in vitro) Shirakabe et al., Genes Cells 2001*
• IRef Hprd Interaction: RUNX2 — MSX2 (in vivo) Shirakabe et al., Genes Cells 2001*
• IRef Ophid Interaction: MSX2 — RUNX2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shirakabe et al., Genes Cells 2001 (Craniosynostoses) : These results suggest that regulation of the activity of Runx2 by Msx2 and Dlx5 plays an important role in the mammalian skull development
Sierra et al., J Biol Chem 2004 : In chromatin immunoprecipitation assays, Msx2 selectively inhibits Runx2 binding to OC chromatin
Hjelmeland et al., Mol Cell Biol 2005 : We further show that negative regulation of Runx2 activity by Smad3 in dermal fibroblasts is likely mediated by controlling the expression of Msx2 , an antagonist of Runx2 in this cellular context
Hayami et al., Matrix Biol 2011 : MMP-13 knockdown produced significant increases only in TGF-ß1, MSX2 and Osx, but decreases in Runx2 and OC. Suppression of both MMPs together resulted in significant increases of all osteoblastic markers except Runx2