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CRK — IFNG

Text-mined interactions from Literome

MacKenzie et al., Biochem J 2000 : Rolipram dose-dependently inhibited the interferon-gamma (IFN-gamma) stimulated phosphorylation of p38 mitogen activated protein ( MAP ) kinase in a simple monotonic fashion with an IC ( 50 ) value of approx. 290 nM
Cannons et al., J Immunol 2000 (MAP Kinase Signaling System) : In contrast, following differentiation into Th1 or Th2 cells, p38 inhibition blocked IL-2 and IFN-gamma without affecting IL-4 secretion
Tsukagoshi et al., Regul Pept 2001 : ANP inhibited the IFN-gamma induced p38 MAP kinase activation, and ANP and SB203580 inhibited NF-kappaB activation
Zhou et al., J Biol Chem 2003 : IFNgamma induced MMP-1 in the presence of GM-CSF through the stimulation of TNFalpha production through a mechanism involving both p38 and ERK1/2 MAPKs, in which GM-CSF stimulated ERK1/2 whereas IFNgamma activated p38
Kulka et al., J Pharmacol Exp Ther 2005 : IFNgamma up-regulation of CFTR in mast cells was inhibited by p38 and extracellular signal regulated kinase ( ERK ) kinase inhibitors but not a Janus tyrosine kinase (JAK)2 inhibitor, whereas in T84 cells IFNgamma mediated down-regulation of CFTR was JAK2 dependent and ERK- and p38 independent
Komine et al., J Invest Dermatol 2005 : RXM partially suppressed p38 phosphorylation and NFkappaB-driven luciferase activity induced by TNFalpha and IFNgamma
Koch et al., Respir Med 2007 (Asthma) : IFNgamma production was dependent on phosphorylation of ERK-1/-2 and p38MAPK , as examined by PD098059, an inhibitor of the upstream activator of MAPKkinase ( MKK-1 ), and SB203580, an inhibitor of p38MAPK ... In conclusion, ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma, and ( 2 ) ERK- and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on IFNgamma release is impaired in asthma
Tassi et al., Immunity 2007 : p110gamma played a major role in receptor induced interferon-gamma (IFN-gamma) production through a pathway that involved the kinase ERK and 5-Lipoxigenase, which most likely generates lipid mediators activating GPRCs. Conversely, PI3Ks negatively regulated interleukin-12 (IL-12) and IL-18 induced IFN-gamma by modulating p38 kinase activation
Guo et al., J Immunol 2008 (Calcium Signaling...) : TCR stimulation also phosphorylates p38, partially through the calcium dependent pathway ; activated p38 is required for optimal IL-4 and IFN-gamma
De Cesaris et al., J Biol Chem 1998 : Moreover, interferon-gamma , which up-regulates adhesion molecule expression and reduces IL-6 production, does not induce phosphorylation of p38