Gene interactions and pathways from curated databases and text-mining

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GRAP2 — TNFSF11

Text-mined interactions from Literome

Park et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : Taken together, these results demonstrate that naturally occurring furosin has an inhibitory activity on both osteoclast differentiation and function through mechanisms involving inhibition of the RANKL induced p38MAPK and JNK/AP-1 activation as well as actin ring formation
Amcheslavsky et al., J Cell Physiol 2006 : Since both RANKL-RANK and CpG-ODN-TLR9 interactions result in NF-kappaB activation, p38 and ERK phosphorylation, and TNF-alpha synthesis ( all implicated in osteoclastogenesis ), we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor
Cheng et al., Food Chem Toxicol 2012 (MAP Kinase Signaling System) : Among the three well known mitogen activated protein kinases ( MAPKs ), Rb1 inhibited RANKL induced JNK and p38 phosphorylation, but not ERK1/2
Hwang et al., Life Sci 2013 : We observed suppression of ERK, JNK, AKT, and p38 mitogen activated protein kinases induced by RANKL in Western blotting after BPA treatment in RAW 264.7 cells