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GRAP2 — TNFSF11
Text-mined interactions from Literome
Park et al., Biochem Biophys Res Commun 2004
(MAP Kinase Signaling System) :
Taken together, these results demonstrate that naturally occurring furosin has an inhibitory activity on both osteoclast differentiation and function through mechanisms involving inhibition of the
RANKL induced
p38MAPK and JNK/AP-1 activation as well as actin ring formation
Amcheslavsky et al., J Cell Physiol 2006
:
Since both
RANKL-RANK and CpG-ODN-TLR9 interactions
result in NF-kappaB activation,
p38 and ERK phosphorylation, and TNF-alpha synthesis ( all implicated in osteoclastogenesis ), we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor
Cheng et al., Food Chem Toxicol 2012
(MAP Kinase Signaling System) :
Among the three well known mitogen activated protein kinases ( MAPKs ), Rb1 inhibited
RANKL induced JNK and
p38 phosphorylation, but not ERK1/2
Hwang et al., Life Sci 2013
:
We observed suppression of ERK, JNK, AKT, and
p38 mitogen activated protein kinases
induced by
RANKL in Western blotting after BPA treatment in RAW 264.7 cells