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EGFR — SOS1

Pathways - manually collected, often from reviews:

• BioCarta role of egf receptor transactivation by gpcrs in cardiac hypertrophy: EGF/EGF R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta egf signaling pathway: EGF/EGF-R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta trefoil factors initiate mucosal healing: TFFs/ErbB1/ERBB2 complex (EGFR-ERBB2-TFF3_TFF2_TFF1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling: EGF-R (EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta keratinocyte differentiation: EGF/EGF-R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta role of erbb2 in signal transduction and oncology: ERBB ligand/ERBB2/ERBB 1/3/4 complex (ERBB2-ERBB4_ERBB3_EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Regulation of actin cytoskeleton: EGFR/FGFR1/FGFR2/FGFR3/FGFR4/INSRR/PDGFRA/PDGFRB → SOS1/SOS2 (protein-protein, activation)
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → mTOR (MTOR) (modification, activates) Iwasaki et al., Endocrinology 1999
  Evidence: mutant phenotype, other species
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
  Evidence: assay
• NCI Pathway Database ErbB1 downstream signaling: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → SOS1 (SOS1) (modification, activates) Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → Eps8/ABI1/SOS1 complex (EPS8-ABI1-SOS1) (modification, activates)
  Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: None → EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: HRAS/GDP complex (HRAS) → EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database Internalization of ErbB1: GRB2 (GRB2) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → EGF (EGF) (modification, collaborate) Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → EGFR (EGFR) (modification, collaborate) Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → SOS1 (SOS1) (modification, collaborate) Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR (EGFR) → SOS1 (SOS1) (modification, collaborate) Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: None → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → None (modification, activates) Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: None → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → None (modification, activates) Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: None → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → None (modification, activates) Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: Vps24 (CHMP3) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (translocation, activates)
  Burke et al., Mol Biol Cell 2001, Ravid et al., J Biol Chem 2004, Mosesson et al., Dev Cell 2009, Levkowitz et al., Genes Dev 1998
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• Reactome Reaction: EGFR → SOS1 (reaction) Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Batzer et al., Mol Cell Biol 1994*, Okutani et al., J Biol Chem 1994*, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995
• Reactome Reaction: EGFR → SOS1 (indirect_complex) Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Batzer et al., Mol Cell Biol 1994*, Okutani et al., J Biol Chem 1994*, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995
• WikiPathways ESC Pluripotency Pathways: EGFR → SOS1/GRB2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SOS1 — EGFR (physical association, affinity chromatography technology) Kurada et al., J Biol Chem 2009*
• IRef Biogrid Interaction: SOS1 — EGFR (physical association, affinity chromatography technology) Tong et al., J Proteome Res 2008
• IRef Biogrid Interaction: SOS1 — EGFR (physical association, affinity chromatography technology) Foerster et al., Proteomics 2013
• IRef Biogrid Interaction: SOS1 — EGFR (physical association, affinity chromatography technology) Qian et al., Mol Cell Biol 1998*
• IRef Biogrid Interaction: SOS1 — EGFR (physical association, affinity chromatography technology) Qian et al., EMBO J 2000*
• IRef Biogrid Interaction: SOS1 — EGFR (direct interaction, pull down) Buday et al., J Biol Chem 1994*
• IRef Biogrid Interaction: SOS1 — EGFR (direct interaction, pull down) Tong et al., Mol Cell Proteomics 2009
• IRef Biogrid Interaction: SOS1 — EGFR (physical association, affinity chromatography technology) Tong et al., Mol Cell Proteomics 2009
• IRef Hprd Interaction: SOS1 — EGFR (in vivo) Qian et al., Mol Cell Biol 1998*
• IRef Intact Interaction: Complex of 228 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Intact Interaction: Complex of 38 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Ophid Interaction: SOS1 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Oh-hora et al., J Exp Med 2003 : The BCR requires RasGRP3 ; in contrast, epidermal growth factor receptor is dependent on Sos1 and Sos2
Wakasaki et al., Neoplasia (New York, N.Y.) 2010 (Carcinoma, Squamous Cell...) : Little is known, however, about a role of CIN85 in EGFR signaling as well as its relevance to tumor development and progression of HNSCC
Schroeder et al., Mol Biol Cell 2012 : In this study we show that EGFR activation leads to a pronounced src mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination