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NFKBIA — TAT

Text-mined interactions from Literome

Blázquez et al., AIDS Res Hum Retroviruses 1999 : Tat induces NF-kappaB binding to DNA as a result of IkappaBalpha phosphorylation and degradation, which depend on the intracellular redox state
Kumar et al., FEBS Lett 1999 : PTPase inhibitors also blocked HIV-tat induced nuclear transcription factor NF-kappaB activation and IkappaBalpha degradation required for MMP-9 induction
Nicolini et al., J Neurochem 2001 : Consistently, Tat induced IkappaBalpha degradation - an index of NF-kappaB activation - was not affected by free radical scavengers, but was prevented by an NF-kappaB-specific inhibitor
Kabouridis et al., J Immunol 2002 (MAP Kinase Signaling System) : In contrast, exogenously added TAT-srIkappaBalpha did not inhibit IL-1beta induced activation of extracellular signal regulated kinase, c-Jun N-terminal kinase, or p38 mitogen activated protein kinases or the phosphorylation and degradation of endogenous IkappaBalpha
Puca et al., J Biol Chem 2007 (Acquired Immunodeficiency Syndrome) : Here, we report that IkappaB-alpha negatively regulates the HIV-1 expression and replication in an NF-kappaB independent manner by directly binding to Tat , which results in the nuclear export and cytoplasmic sequestration of the viral transactivator
Lee et al., Exp Mol Med 2009 : Tat-SOD inhibited LPS induced NF-kappaB DNA binding activity, IkappaBalpha degradation and activation of MAP kinases
Beauparlant et al., J Virol 1996 : Coexpression of I kappa B alpha inhibited Tat-TNF-alpha activation of HIV LTR in a dose dependent manner