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HRAS — IL2

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• Reactome Reaction: IL2 → HRAS (reaction) Chardin et al., Science 1993

Text-mined interactions from Literome

Duronio et al., Proc Natl Acad Sci U S A 1992 : We demonstrate here that ligand induced activation of the interleukin (IL)-2 , IL-3, IL-5, and granulocyte-macrophage colony stimulating factor receptors resulted in activation of p21ras in various hemopoietic cell lines
Graves et al., J Immunol 1992 : IL-2 causes a rapid and prolonged activation of p21ras in both murine and human T cells ... The concentration-dependence of IL-2 mediated stimulation of p21ras correlated with IL-2 stimulation of T cell proliferation, which indicates that p21ras activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor
Izquierdo et al., Eur J Immunol 1992 : Interleukin (IL)-2 activation of p21ras in murine myeloid cells transfected with human IL-2 receptor beta chain ... The T cell growth factor interleukin-2 (IL-2) induces p21ras activation in T lymphocytes ... To determine whether the IL-2 receptor (IL-2R) can regulate p21ras when expressed in a non-T cell environment we have examined the ability of IL-2 to activate p21ras in 32D murine myeloid progenitor cells transduced with human IL-2R beta chains ... Our data show that IL-3 is able to activate p21ras in the parental 32D cells and both IL-2 and IL-3 can stimulate p21ras in the IL-2R expressing beta 53 clone of 32D
Izquierdo et al., Eur J Immunol 1993 : The T cell growth factor interleukin-2 (IL-2) induces p21ras activation in T lymphocytes ... Our data show that in conditions where cellular protein tyrosine kinases ( PTK ) were efficiently down-regulated by pretreatment with the specific PTK inhibitor herbimycin, the IL-2 induced activation of p21ras was blocked
Galandrini et al., J Exp Med 1996 : We also present evidence that p21ras is activated by CD16 and IL-2R cross linking
Neumann et al., Eur J Immunol 1996 (Multiple Myeloma) : Like many other cytokines and growth factors, interleukin-6 (IL-6) activates p21ras
Rao et al., Cell Growth Differ 1995 (Lymphoma, T-Cell) : Rapid activation of mitogen activated protein kinase and p21ras by prolactin and interleukin 2 in rat Nb2 node lymphoma cells