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C1ORF228 — IRF6

Text-mined interactions from Literome

Kitagawa et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : IL-12 p40 production was also increased by LPS stimulation ... The TNFalpha inhibitor rolipram inhibited LPS stimulated IL-12 p40 production by RA SC more strongly than spontaneous production
Ma et al., J Immunol 2000 : The major transcriptional factors identified to be involved in the regulation of IL-12 p40 gene expression by LPS and IFN-gamma, i.e., c-Rel, NF-kappaB p50 and p65, IFN regulatory factor-1, and ets-2, were not affected by TNF-alpha when examined by nuclear translocation and DNA binding
Dai et al., Immunology 2001 : In this study, GL showed a dose dependent priming effect on lipopolysaccharide (LPS) induced IL-12 p40 and IL-12 p70 ( heterodimer of p40 and p35 ) protein production by peritoneal macrophages ( PM )
Petro et al., Int Immunopharmacol 2002 : Both p70 and p40 are produced by macrophages in response to lipopolysaccharide (LPS) , IFN-gamma and/or CD40 ligation
Mason et al., J Immunol 2002 (Inflammation...) : Recent studies have shown that c-Rel, a member of the NF-kappaB family of transcription factors, is essential for LPS induced IL-12p40 production by macrophages
Bradford et al., J Biomed Sci 2002 : The regulation of macrophage IL-12 p40 secretion in response to stimulation with LPS and interferon-gamma (IFN-gamma) is dependent on the action of a nuclear transacting factor, interferon consensus sequence binding protein ( ICSBP ), a STAT1 dependent gene product
Feng et al., Cell Res 2002 (Inflammation) : The present study examined a possible molecular mechanism involved in cAMP elevators induced inhibition of IL-12 p40 expression in response to LPS
Litjens et al., J Invest Dermatol 2004 (Psoriasis) : No association was observed between the various IL12B promoter genotypes and the LPS stimulated production of IL-12p70 or IL-12p40 by blood cells
Matsumoto et al., J Immunol 2004 (Inflammation) : The fact that simvastatin potently augments LPS induced IL-12p40 and TNF-alpha production has implications for the treatment of bacterial infections in statin treated patients
Correa et al., Br J Pharmacol 2005 : 3 The inhibitory effect of JWH-133 ( 100 nM ) on IL-12p40 production may involve extracellular regulated kinase ( ERK1/2 ) signaling : ( i ) JWH-133 induced a greater and sustained activation of ERK1/2 kinase in comparison with the level of activation observed following LPS ; ( ii ) the inhibition of ERK1/2 by the specific inhibitor PD98059 increased LPS induced IL-12p40 production in the presence or absence of JWH-133 suggesting a negative regulation of ERK pathway on IL-12p40 biosynthesis ... In contrast, the addition of exogenous mIL-10 reduced the secretion of IL-12p40 in response to LPS
Fronhofer et al., J Leukoc Biol 2006 : Similarly, activation of PKC with phorbol 12-myristate 13-acetate ( PMA ) depressed LPS stimulated IL-12p40 secretion, and depletion of PKC augmented LPS stimulated IL-12p40 secretion
An et al., J Ethnopharmacol 2006 : However, GH increased IFN-gamma/LPS induced IL-12p40 production
Ma et al., J Biol Chem 2009 (Acquired Immunodeficiency Syndrome) : Herein, we show that intracellular nef expressed through transduction of primary monocytes and promonocytic THP-1 cells with retroviral mediated nef gene inhibited LPS induced IL-12p40 transcription by inhibiting the JNK mitogen activated protein kinases without affecting the calmodulin dependent protein kinase-II activated pathway
Yamauchi et al., International journal of biological sciences 2009 : AZM also reduced LPS/IFN-gamma induced IL-12p40 promoter activity
Louis et al., J Leukoc Biol 2010 (HIV Infections) : Intracellular p40 expression by monocytes and cDCs, analyzed by flow cytometry, was transiently increased in monocytes and cDCs in response to LPS and more consistently, in monocytes in response to LPS + IFN-gamma
Al-Mutairi et al., PLoS Pathog 2010 (Leishmaniasis, Cutaneous) : MKP-2 deletion also potentiated LPS stimulated induction of the inflammatory cytokines, IL-6, IL-12p40 , TNF-a, and also COX-2 derived PGE ( 2 ) production
Menzies et al., Immunology 2011 : Analysis of mRNA expression, by quantitative reverse transcription-polymerase chain reaction ( qRT-PCR ), of genes associated with innate and alternative macrophage activation revealed that progesterone down-regulated LPS induced macrophage nos2, argI and p40 ( IL-12/IL-23 ) expression and IL-4 induced argI, mrc-1 and fizz1 expression
Jung et al., Arterioscler Thromb Vasc Biol 2012 : Eicosapentaenoic acid alone or with LPS blunted LPS mediated stimulation of macrophage proinflammatory interleukin-6, interleukin-12p40 , and toll-like receptor-4 mRNA and increased anti-inflammatory interleukin-10 and mannose receptor mRNA
Cassatella et al., Eur J Immunol 1995 : Therefore, the combined effect of LPS and IFN-gamma induced sufficient expression of both p40 and p35 to attain production of the biologically active p70 heterodimer at physiologically relevant concentrations
Heinzel et al., J Immunol 1996 (Endotoxemia) : The addition of rIFN-gamma to IFN-gamma 0/0 splenocyte culture restored normal levels of LPS stimulated IL-12 p40 production
Aloisi et al., J Immunol 1997 : Combined stimulation with IFN-gamma/LPS enhances IL-12 p40 secretion and induces IL-12 p75 secretion by microglia