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IRF1 — IRF6

Pathways - manually collected, often from reviews:

• BioCarta the information processing pathway at the ifn beta enhancer: IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1) → IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  

Text-mined interactions from Literome

Xi et al., Oncogene 1999 (Pancreatic Neoplasms) : Here we report that the human CIITA Type IV promoter IRF-E binds IRF-1 and can be activated by exogenous expression of IRF-1
Ohmori et al., J Leukoc Biol 2001 : LPS induced expression of an interferon ( IFN ) -inducible 10-kDa protein ( IP-10 ), IFN regulatory factor-1 (IRF-1) , and inducible nitric oxide synthase (iNOS) mRNAs was severely impaired in macrophages prepared from Stat1-/- mice, whereas levels of tumor necrosis factor alpha and KC ( a C-X-C chemokine ) mRNA in LPS treated cell cultures were unaffected ... Activation of these STAT1 containing transcription factors was mediated by the intermediate induction of type I IFNs, since the LPS induced IP-10, IRF-1 , and iNOS mRNA expression was markedly reduced in macrophages from IFN-alpha/betaR-/- mice and blocked by cotreatment with antibodies against type I IFN ... Activation of these STAT1 containing transcription factors was mediated by the intermediate induction of type I IFNs, since the LPS induced IP-10, IRF-1 , and iNOS mRNA expression was markedly reduced in macrophages from IFN-alpha/betaR-/- mice and blocked by cotreatment with antibodies against type I IFN
Inoue et al., J Rheumatol 2001 (Arthritis, Experimental...) : LPS induced IFN-beta and IRF-1 gene expression were markedly suppressed by KE-758
Liu et al., Br J Pharmacol 2001 : 1. In this study we examined the signalling events that regulate lipopolysaccharide (LPS) stimulated induction of interferon regulatory factor (IRF)-1 in human umbilical vein endothelial cells ( HUVECs ) ... Preincubation with the Janus kinase (JAK)-2 inhibitor, AG490 blocked LPS stimulated IRF-1 induction but did not affect GAS/GAF DNA binding
Xi et al., Mol Immunol 2003 : Off-rate experiments revealed that the IRF-2/IRF-E complex was more stable than the IRF-1/IRF-E complex and that the affinity of IRF-1 for the IRF-E was increased when IRF-1 co-occupied the IRF-E with IRF-2
Hemmi et al., J Exp Med 2004 (Virus Diseases) : Viral infection and stimulation with lipopolysaccharide (LPS) or double stranded RNA ( dsRNA ) induce phosphorylation of interferon ( IFN ) regulatory factor ( IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction
Kollet et al., Mol Immunol 2006 : IFN-gamma or LPS stimulate nuclear localization of IRF-1 or cRel/p50, respectively, in the RAW 264.7 macrophage cell line
Choi et al., J Neurosci Res 2005 (Alcohol-Induced Disorders, Nervous System...) : Lipopolysaccharide (LPS), gangliosides, and interferon (IFN)-gamma induced the inflammatory activation of glia, which was differentially influenced by ethanol : 1 ) ethanol inhibited LPS- or gangliosides induced, but not IFNgamma induced, glial activation as demonstrated by the production of nitric oxide and the expression of inflammatory genes such as interleukin-1beta, tumor necrosis factor-alpha, IP-10, and CD86 ; 2 ) nuclear factor (NF)-kappaB or JAK/STAT1 pathway was necessary for LPS- or IFNgamma induced glial activation, respectively ; 3 ) ethanol inhibited LPS induced NF-kappaB activation ; and 4 ) ethanol did not significantly affect IFNgamma induced STAT1/IRF-1 activation
Guo et al., J Immunol 2005 : IRF-2 constitutively binds to the two ISRE/IRF-E sites at the DRR, while IRF-1 and STAT1 are induced to bind to the two ISRE/IRF-E sites and the ISRE/IRF-E1, respectively, only after IFN-beta treatment
Nencioni et al., Blood 2006 : As a suitable mechanism for these effects, bortezomib was found to down-regulate MyD88, an essential adaptor for TLR signaling, and to relieve LPS induced activation of NF-kappaB, IRF-3 , and IRF-8 and of the MAP kinase pathway
Arjcharoen et al., Infect Immun 2007 : Unlike the wild type, the LPS mutant could readily stimulate Y701-STAT-1 phosphorylation ( pY701-STAT-1 ) and interferon-regulatory factor 1 (IRF-1) expression, both of which are essential transcription factors of iNOS
Koide et al., J Endotoxin Res 2007 : LPS significantly augmented the activation of interferon regulatory factor (IRF)-1 in IFN-gamma stimulated END-D cells, although it did not affect the activation of either MyD88 dependent nuclear factor (NF)-kappaB or MyD88 independent IRF-3
Abe et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation...) : Statins inhibited TLR4 mediated activation of interferon ( IFN ) regulatory factor ( IRF)3 by either lipopolysaccharide (LPS) or palmitic acid, resulting in suppression of IFN-beta expression, but not that of NF-kappaB or JNK
Pan et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 (Leukemia, Promyelocytic, Acute) : It is concluded that during ATRA induced APL cell differentiation, IRF-1 is first upregulated by ATRA, and then IRF-1 increases the protein levels of IRF-9 and STAT2 with the downregulation of C/EBPalpha
Sheikh et al., J Biol Chem 2011 (Chronic Disease...) : Functionally, IRF-1 is a negative regulator of Il23a in LPS stimulated BMMs. IRF-1 ( -/- ) BMMs demonstrated enhanced LPS induced Il23a expression compared with WT BMMs
Ogasawara et al., Journal of clinical biochemistry and nutrition 2011 : Rebamipide reduced the expression of TBK1, IRF3 and IRF7 mRNA induced by LPS/dsRNA , but not of NF-?B mRNA in colonic epithelial cells
Ke et al., Hepatology 2013 (Disease Models, Animal...) : In contrast, knockdown of ß-catenin increased PTEN/TLR4 ( Toll-like receptor 4 ), interferon regulatory factor-3 (IRF3), nuclear factor kappa B ( NF-?B ) activity, and proinflammatory cytokine programs in response to LPS stimulation
Pan et al., Chin Med J (Engl) 2013 : IRF-1 plays a role in LPS induced release of HMGB1 and therefore may serve as a novel target in sepsis
Kondo et al., Hokkaido Igaku Zasshi 1996 (Leukemia...) : Functional analysis showed that IRF-BP inhibited DNA binding and transcriptional activity of IRF-1
Hattori et al., Biochem Mol Biol Int 1996 : In contrast, expression of IFN-beta and IRF-1 genes in response to LPS was potentiated in the presence of CHX
Cheng et al., J Interferon Cytokine Res 1998 : A requirement for Stat1 binding to ISRE for IFN-gamma and IFN regulatory factor-1 (IRF-1) binding to ISRE for LPS , poly ( I:C ), and virus has been reported
Faure et al., J Biol Chem 1999 : The decrease of LPS/IFN-gamma induced IRF-1 promoter activity, IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds ... The decrease of LPS/IFN-gamma induced IRF-1 promoter activity, IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds