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EPHB2 — GHSR

Text-mined interactions from Literome

Chan et al., FEBS Lett 2004 : Furthermore, the ability of the GHSR antagonist D-Lys3-GHRP-6 to inhibit basal PLC and basal ERK1/2 activity suggests that this compound is an inverse agonist
Mousseaux et al., Br J Pharmacol 2006 : 4. We then investigated the precise mechanisms involved in GHSR-1a mediated ERK1/2 activation using various specific inhibitors and dominant negative mutants and found that internalization of GHSR-1a was not necessary ... Our results also indicate that phospholipase C (PLC) was involved in GHSR-1a mediated ERK1/2 activation, however, pathways like tyrosine kinases, including Src, and phosphoinositide 3-kinases were not found to be involved ... GHSR-1a mediated ERK1/2 activation was abolished both by a general protein kinase C ( PKC ) inhibitor, Gö6983, and by PKC depletion using overnight pretreatment with phorbol ester ... Moreover, the calcium chelator, BAPTA-AM, and the inhibitor of conventional PKCs, Gö6976, had no effect on the GHSR-1a mediated ERK1/2 activation, suggesting the involvement of novel PKC isoforms ( epsilon, delta ), but not conventional or atypical PKCs