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EPHB2 — JAK3

Text-mined interactions from Literome

Takaoka et al., EMBO J 1999 : Thus, the two types of IFN may utilize distinct Jak mediated Erk2 , and possibly other MAPK activation pathways for their antiviral action
Niculescu et al., Immunopharmacology 1999 : Therefore, JAK1 activity may be involved in activation of Raf-1 and ERK1 via G proteins activated by C5b-9
Zhu et al., J Leukoc Biol 2002 : ERK1/2 phosphorylation and eosinophil adhesion were blocked by inhibition of the src-family tyrosine kinase, Janus tyrosine kinase (JAK)2 , or phosphoinositide-3 kinase (PI3K)
Pai et al., Biochem Biophys Res Commun 2005 (Stomach Neoplasms) : While JAK inhibition with AG490 significantly reduced leptin induced ERK2 , STAT3 phosphorylation, and cell proliferation, SHP2 inhibition only partially reduced cancer cell proliferation
Wang et al., Blood 2006 (MAP Kinase Signaling System...) : TCCM treatment activated p38 mitogen activated protein kinase ( MAPK ) and Janus kinase ( JNK ) but inhibited extracellular regulated kinase (ERK)
Sharma et al., Endocr Relat Cancer 2006 (Endometrial Neoplasms...) : Moreover, leptin induced phosphorylation of ERK2 and AKT was dependent on JAK/STAT activation
Cao et al., J Hepatol 2007 (Liver Cirrhosis...) : The repression was mediated by JAK/STAT pathway in synergism with JAK mediated H2O2 dependent ERK1/2 and p38 pathways ... Leptin represses MMP-1 gene expression via the synergistic actions of the JAK/STAT pathway and JAK mediated H2O2 dependent ERK1/2 and p38 pathways
El Mabrouk et al., Biochim Biophys Acta 2007 : Furthermore, JAK3 inhibition time-dependently down-regulated Akt but not ERK1/2 phosphorylation suggesting that Akt is a downstream target of JAK3
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin induced phosphorylation of JAK2 and ERK , whereas IFN-gamma induced phosphorylation of JAK1, JAK2 , and p38 MAPK
Saxena et al., Cancer Res 2007 (Carcinoma, Hepatocellular...) : Leptin induced phosphorylation of ERK and AKT was dependent on Janus activated kinase ( JAK ) /STAT activation
Luo et al., Eur J Neurosci 2007 (Optic Nerve Injuries) : In this study we showed that : ( i ) the RGC protection was pathway inhibition dependent ; ( ii ) inhibition of PI3K/akt and JAK/STAT, but not MEK/ERK , activated macrophages in the eye, ( iii ) macrophage removal from the eye using clodronate liposomes significantly impeded PI3K/akt and JAK/STAT inhibition induced RGC survival and axon regeneration whereas it only slightly affected MEK/ERK inhibition dependent protection ; ( iv ) in the absence of recruited macrophages in the eye, inhibition of PI3K/akt or JAK/STAT did not influence RGC survival ; and ( v ) strong PI3K/akt, JAK/STAT and MEK/ERK pathway activities were located in RGCs but not macrophages after ON injury
Trimarchi et al., J Neurochem 2009 : These results indicate that CNTF evoked stimulation of T-type Ca ( 2+ ) channel expression in chicken nodose neurons requires JAK dependent ERK signaling
Kim et al., Cell Signal 2009 (Breast Neoplasms) : Therefore, for the first time, we suggest that the JAK3 inhibitor, WHI-P131, inhibits EGF induced STAT-3 phosphorylation as well as ERK phosphorylation
Sengupta et al., Proc Natl Acad Sci U S A 1998 : These results demonstrate an ERK mediated mechanism for inhibiting IL-6 induced Jak-STAT signaling that is rapid and inducible, and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway