◀ Back to EPHB2

EPHB2 — TMED7

Text-mined interactions from Literome

Teixeira et al., J Neurochem 2000 : Our results suggest that ET-1 induced expression of cyclins D1 and D3 is dependent on the ERK- and CSK dependent pathways, respectively ; moreover, a decrease in the levels of the cyclin dependent kinase inhibitor (CKI) p27 was observed as a consequence of ERK activation
Das et al., FEBS Lett 2000 : This implies that a link exists between ERK activation and p21 ( WAF ) and p27 ( kip1 ) induction in the process of terminal differentiation
He et al., Immunol Lett 2005 : Inhibiting ERK activation reduced the increased expression of p27 and Bax, but had no effect on the decreased expression of Bcl-2, suggesting the involvement of ERK activation in the SN-induced increased expression of p27 and Bax
Sakakibara et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Conversely, direct activation of ERK via adenovirus mediated expression of a constitutively active form of MEK led to a reduction of p27 protein and mRNA, further supporting the central role of ERK in regulation of p27 expression
Hu et al., Mol Biol Cell 2005 : Furthermore, in response to H2O2, inhibition of ERK activation repressed p66shcA dependent phosphorylation of FOXO3a and the down-regulation of its target gene p27kip1
Bagui et al., Cell cycle (Georgetown, Tex.) 2009 : Inhibition of p27 ( Kip1 ) gene expression by PDGF required protein synthesis and histone deacetylase activity but not Akt or ERK activity
Pearson et al., Breast Cancer Res 2009 (Disease Progression...) : Both ERK1/2 and PI-3 kinase dependent effector pathways were required for activated Raf : ER to reduce expression of p27 and promote proliferation
Okumura et al., J Gastroenterol 2010 (Gastrointestinal Neoplasms...) : p27 ( Kip1 ) accumulation results from the inhibition of the ubiquitin-proteasome system and/or inhibition of MEK-ERK signaling
Gopinath et al., Mol Oncol 2011 (Glioma) : In the present study, shRNA against cathepsin B and uPAR as well as specific inhibitors, Wortmannin ( 10 µM ) and U0126 ( 10 µM ), were used to determine the roles of AKT and ERK signaling on p27 expression ... Immunoblot analysis demonstrated that downregulation of both p-ERK and p-AKT downstream of EGFR and ß1 integrin are involved in the p27 upregulation
Huang et al., PloS one 2012 (Endometrial Neoplasms) : The present studies demonstrate that E2 stimulates growth of ECA cell lines and normal primary endometrial epithelial cells ( EECs ) and induces MAPK-ERK1/2 dependent phosphorylation of p27 on Thr187, a prerequisite for p27 ubiquitylation by nuclear SCF-Skp2/Cks1 and subsequent degradation
McKinley et al., J Nucl Med 2013 (Colorectal Neoplasms...) : Reduced F-FLT PET reflected a modest, yet significant, reduction of Ki67 immunoreactivity, inhibition of p-MEK and p-ERK , and elevated tumor cell p27 protein levels