◀ Back to SYT1

SNAP25 — SYT1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Effects of Botulinum toxin: STX1A/SNAP25/VAMP2 complex (STX1A-SNAP25-VAMP2) → ACh/Synaptotagmin 1 complex (SYT1) (modification, activates)
  
• NCI Pathway Database Effects of Botulinum toxin: STX1A/SNAP25 fragment 1/VAMP2 complex (STX1A-SNAP25-VAMP2) → ACh/Synaptotagmin 1 complex (SYT1) (modification, activates)
  
• NCI Pathway Database Effects of Botulinum toxin: SNAP25 fragment 2 (SNAP25) → ACh/Synaptotagmin 1 complex (SYT1) (modification, inhibits)
  
• Reactome Reaction: SYT1 → SNAP25 (reaction) Augustin et al., Nature 1999, Deken et al., Nat Neurosci 2000, Barclay et al., J Biol Chem 2003, Gasnier et al., Pflugers Arch 2004, Toonen et al., J Neurochem 2005, Quick et al., Handb Exp Pharmacol 2006, Dulubova et al., Proc Natl Acad Sci U S A 2007, Martens et al., Science 2007, Stein et al., Nature structural & molecular biology 2007, Khvotchev et al., J Neurosci 2007, Binda et al., Mol Pharmacol 2008, Koch et al., Curr Opin Neurobiol 2009, Riento et al., J Cell Sci 1998
• Reactome Reaction: SYT1 → SNAP25 (indirect_complex) Augustin et al., Nature 1999, Toonen et al., J Neurochem 2005, Quick et al., Handb Exp Pharmacol 2006, Dulubova et al., Proc Natl Acad Sci U S A 2007, Khvotchev et al., J Neurosci 2007, Binda et al., Mol Pharmacol 2008, Riento et al., J Cell Sci 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SYT1 — SNAP25 (physical association, affinity chromatography technology) Zhang et al., Cell Mol Life Sci 2013*
• IRef Biogrid Interaction: SYT1 — SNAP25 (direct interaction, pull down) Gerona et al., J Biol Chem 2000*
• IRef Biogrid Interaction: SYT1 — SNAP25 (direct interaction, pull down) Zhang et al., Neuron 2002*
• Gene Ontology Complexes SNARE complex: SNARE complex complex (STX1A-SNX4-VAMP8-STX16-NPEPL1-BET1L-DOC2B-SNAP25-YKT6-CPLX2-GOSR2-CPLX1-BNIP1-STX8-VAMP3-VAMP5-VAMP4-VAMP7-SYT1-STX3-STX7-STX6-STX11-STX12-VTI1A-STX16-STX19) Fernández-Chacón et al., Annu Rev Physiol 1999, Polgár et al., Blood 2002, Tian et al., J Biol Chem 2003, Pryor et al., EMBO Rep 2004, Tai et al., Mol Biol Cell 2004, Sudhof et al., Annu Rev Neurosci 2004, Nakajima et al., EMBO J 2004, Sander et al., Eur J Immunol 2008, Ghiani et al., Mol Psychiatry 2010, Pérez-Victoria et al., Mol Cell Biol 2009, Itakura et al., Cell 2012, Pirooz et al., Proc Natl Acad Sci U S A 2014
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Betz et al., J Biol Chem 1997*
• IRef Hprd Interaction: SYT1 — SNAP25 (in vitro) Gerona et al., J Biol Chem 2000*
• IRef Ophid Interaction: SNAP25 — SYT1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Verona et al., J Neurochem 2000 : Stimulation of Ca2+/calmodulin dependent protein kinase II, which endogenously phosphorylates synaptotagmin in synaptic vesicles, increased the interaction of syntaxin and SNAP-25 with synaptotagmin ( particularly when measured in the presence of calcium ), as well as increasing the binding of the kinase itself
Chang et al., Exp Mol Med 2004 : SNAP also blocked cytokine- induced increase in NF-kappaB activation, iNOS promoter activity, nuclear translocation of cytosolic NF-kappaB p65 subunit, and IkappaBalpha degradation, which correlated with its inhibitory effect on phosphorylation and ubiquitination of IkappaB
Lopez et al., FASEB J 2007 : Previous studies indicate that the process requires Rab3 dependent tethering of membranes, SNARE complex assembly, and Ca2+ mediated activation of synaptotagmin