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APAF1 — CYCS

Pathways - manually collected, often from reviews:

• KEGG Tuberculosis: BAX → Complex of APAF1-CASP9-CYCS (protein-protein, activation)
  
• KEGG Tuberculosis: Complex of APAF1-CASP9-CYCS → CASP3 (protein-protein, activation)
• KEGG Tuberculosis: BCL2 → Complex of APAF1-CASP9-CYCS (protein-protein, inhibition)
  
• Reactome Reaction: APAF1 → CYCS (reaction) Zou et al., Cell 1997*, Li et al., Cell 1997*
• Reactome Reaction: APAF1 → CYCS (direct_complex) Zou et al., Cell 1997*
• WikiPathways Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation: CYCS → CASP9/APAF1 (activation)
• WikiPathways Nanomaterial induced apoptosis: CYCS → APAF1 (activation)
• WikiPathways Oxidative Damage: CYCS → APAF1/CASP9 (activation)
• WikiPathways Apoptosis Modulation by HSP70: CYCS → CYCS/APAF1/CASP9 (activation)
• WikiPathways Apoptosis: CYCS → APAF1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: APAF1 — CYCS (physical association, affinity chromatography technology) Zou et al., Cell 1997*
• MIPS CORUM Apoptosome: Apoptosome complex (APAF1-CYCS) Yu et al., Structure 2005*
• MIPS CORUM Apoptosome-procaspase 9 complex: Apoptosome-procaspase 9 complex complex (APAF1-CASP9-CYCS) Cain et al., J Biol Chem 2000*
• IRef Corum Interaction: APAF1 — CYCS (association, x-ray crystallography) Yu et al., Structure 2005*
• IRef Hprd Interaction: APAF1 — CYCS (in vivo) Zhang et al., Neurosci Lett 2002*, Zou et al., Cell 1997*
• IRef Hprd Interaction: Complex of CASP9-CYCS-APAF1-APAF1-CASP9-CASP9-CYCS-APAF1-CYCS (in vivo) Zou et al., J Biol Chem 1999*
• IRef Intact Interaction: APAF1 — CYCS (physical association, coimmunoprecipitation) Zou et al., Cell 1997*
• IRef Intact Interaction: APAF1 — CYCS (physical association, pull down) Zou et al., J Biol Chem 1999*
• IRef Intact Interaction: Complex of 13 proteins (physical association, cosedimentation) Zou et al., J Biol Chem 1999*
• IRef Ophid Interaction: APAF1 — CYCS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: APAF1 — CYCS (aggregation, confirmational text mining) Zhang et al., Neurosci Lett 2002*

Text-mined interactions from Literome

Chauhan et al., J Biol Chem 2001 (Multiple Myeloma) : Apaf-1/cytochrome c-independent and Smac dependent induction of apoptosis in multiple myeloma ( MM ) cells
Bratton et al., Cell Death Differ 2001 : Cytochrome c and dATP/ATP induce oligomerization of Apaf-1 into two distinct apoptosome complexes : an approximately 700 kDa complex, which recruits and activates caspases-9, -3 and -7, and an approximately 1.4 MDa complex, which recruits and processes caspase-9, but does not efficiently activate effector caspases
Henshall et al., Cell Death Differ 2001 (Seizures) : In this study we examine the in vivo formation of the Apaf-1/cytochrome c complex and activation of caspase-9 following limbic seizures in the rat ... These data suggest seizures induce formation of the Apaf-1/cytochrome c complex prior to caspase-9 activation and caspase-9 may be a potential therapeutic target in the treatment of brain injury associated with seizures
Cain et al., Drug Metab Rev 2003 : Cytochrome c activates Apaf-1 , which oligomerizes to form an approximately 700-1400-kDa caspase activating complex known as the Apaf-1 apoptosome
Cao et al., J Neurosci 2004 (Brain Ischemia...) : Cytochrome c-initiated activation of apoptotic protease activating factor-1 ( Apaf-1 ) is a key step in the mitochondrial signaling pathway for the activation of death executing caspases in apoptosis