Yang et al., Eur J Immunol 1999
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As is the case for the IL-2 promoter, transcription of the IL-4 promoter is enhanced by overexpression of wild-type Tec but inhibited by overexpression of a kinase-dead version of Tec following CD28 activation
Zemans et al., Cell Immunol 2009
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Furthermore, LPS induced actin polymerization as well as MCP-1, tumor necrosis factor-alpha, interleukin-6 , and interleukin-1beta expression are dependent on Tec kinase activity