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APH1B — NOTCH2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Notch signaling pathway:
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
→
NOTCH2 heterodimer/CNTN1 complex (NOTCH2-CNTN1)
(modification, activates)
Shimizu et al., Mol Cell Biol 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Hu et al., Cell 2003, Fraering et al., Biochemistry 2004
Evidence: mutant phenotype, assay
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NCI Pathway Database Notch signaling pathway:
NEXT2 (NOTCH2)
→
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
(modification, collaborate)
Shimizu et al., Mol Cell Biol 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Fraering et al., Biochemistry 2004
Evidence: mutant phenotype, assay
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Reactome Reaction:
NOTCH2
→
APH1B
(reaction)
De Strooper et al., Nature 1999, Saxena et al., J Biol Chem 2001, Fortini et al., Nat Rev Mol Cell Biol 2002, Schroeter et al., Nature 1998
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WikiPathways Notch Signaling Pathway:
APH1A/APH1B/TNF/PSEN1/PSEN2/NCSTN
→
NOTCH2/NOTCH3/NOTCH4/NOTCH1
(activation)
Text-mined interactions from Literome
Mumm et al., Mol Cell 2000
:
Gamma-secretase-like proteolysis at site 3 ( S3 ), within the transmembrane domain, releases the Notch intracellular domain ( NICD ) and
activates CSL mediated
Notch signaling
Curry et al., Oncogene 2005
(Sarcoma, Kaposi) :
Gamma secretase inhibitor
blocks Notch activation and induces apoptosis in Kaposi 's sarcoma tumor cells
Koyanagi et al., Circ Res 2007
:
Gamma-secretase dependent
Notch activation is required for cardiac gene expression in human cells and induces the expression of noncanonical Wnt proteins, which may act in a paracrine manner to further amplify cardiac differentiation
Shimoyama et al., Arterioscler Thromb Vasc Biol 2010
(Diabetes Mellitus, Experimental...) :
Gamma secretase inhibitor, an
inhibitor of
Notch signaling, partially inhibited the enhanced expression of p21 induced by CCN3