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CCR7 — IRF6
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Giordano et al., J Immunol 2003
:
Treatment during DC differentiation with either cAMP or cGMP analogues hampered
LPS induced expression of CD83, DC-LAMP, and
CCR7 and the ability of DCs to migrate toward CCL19/macrophage-inflammatory protein 3beta
Vizzardelli et al., Eur J Immunol 2006
:
Among the counteracting effects we have observed an inhibition of Dex on the
LPS induced up-regulation of the chemokine receptor
CCR7
Amat et al., Br J Pharmacol 2006
(Arthritis) :
Surprisingly,
CCR1 knockout mice produced more TNFalpha than controls in
response to
LPS , and J-113863 decreased TNFalpha also in CCR1 null mice, indicating that its effect was unrelated to CCR1
Li et al., Blood 2007
(MAP Kinase Signaling System) :
Specific inhibition of ERK during CB DC maturation enhanced
LPS induced up-regulation of
CCR7 and CXCR4 on CB DCs and their chemotaxis toward CCL19 and CXCL12, to a level similar to that of mature AB DCs ... Overall, monocyte derived CB DCs responded to LPS with stronger and sustained ERK activation, which negatively correlated with
LPS induced up-regulation of
CCR7 and CXCR4 on CB DCs and their migratory responses
Liu et al., Mol Immunol 2007
:
Further studies show that the triptolide mediated inhibitory effects of
LPS induced activation of phosphatidylinositol-3 kinase (PI3-K)/Akt and nuclear NF-kappaB activation are
involved in down-regulation of COX-2 and
CCR7 expression resulting in impaired migration to secondary lymphoid organs of DC
Jiang et al., J Immunol 2007
:
NGF could markedly promote
LPS induced expression of HLA-DR, CD40, CD80, CD83, CD86,
CCR7 , secretion of IL-12p40 and proinflammatory cytokines IL-1, IL-6, TNF-alpha, and the T cell stimulating capacity of MoDCs, indicating that NGF can promote LPS induced DC maturation
Thomas et al., Clin Exp Immunol 2009
:
Culture of primary ( native, non-monocyte derived ) human myeloid CD1c+CD11c+CD123 ( - ) DC ( mDC ) in the presence of Sb culture supernatant ( active component molecular weight < 3 kDa, as evaluated by membrane partition chromatography ) reduced significantly expression of the co-stimulatory molecules CD40 and CD80 ( P < 0.01 ) and the DC mobilization marker CC-chemokine receptor
CCR7 ( CD197 ) ( P < 0.001 )
induced by the prototypical microbial antigen
lipopolysaccharide (LPS)
van de Laar et al., J Immunol 2010
:
Although dispensable for costimulatory molecule expression, the PI3K-PKB-mTOR signaling module was required for other important processes associated with DC function, including Ag uptake,
LPS induced cytokine secretion,
CCR7 expression, and T cell stimulation
Sica et al., J Exp Med 1997
:
The present study was designed to investigate the
effect of bacterial
lipopolysaccharide (LPS) on C-C
chemokine receptors ( CCR ) expressed in human mononuclear phagocytes
Minami et al., Toxicology 1998
:
We investigated the penetration of cisplatin into the mouse cerebral
cortex-rich region ( CCR ) induced by
lipopolysaccharide (LPS) ... At doses of 500 mg/kg aminoguanidine, however, no effect was seen on the platinum level of the
CCR induced by
LPS