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IRF6 — UMOD

Text-mined interactions from Literome

Yamamoto et al., Drug design and discovery 1999 : We studied the inhibitory effects of various hydroxamate MMP inhibitors on FasL and TNF-alpha processing in order to characterize the processing enzymes using human FasL cDNA transfectants and LPS stimulated THP-1 cells
Zaman et al., Hokkaido Igaku Zasshi 2000 : In addition, the reverse transcription polymerase chain reaction demonstrated reduced expression of TF mRNA in LPS stimulated THP-1 cells exposed to FK-506
Schwartz et al., Am J Physiol Lung Cell Mol Physiol 2001 (Bronchial Hyperreactivity...) : In preliminary studies, we found that these LPS antagonists did not act as agonists in vitro ( THP-1 cells ) or in vivo ( after intratracheal instillation of 10 microg ) and that these compounds ( at least 1 microg/ml ) effectively antagonized the release of tumor necrosis factor-alpha by LPS stimulated THP-1 cells
Dreskin et al., J Immunol 2001 : The p54 JNK that is phosphorylated in LPS stimulated , PMA differentiated THP-1 cells is most likely JNK2alpha2 because 97 % of the p54 JNK encoding messages code for JNK2alpha2
Fujigaki et al., Eur J Immunol 2001 : IFN-gamma independent IDO induction was also demonstrated in vitro with LPS stimulated monocytic THP-1 cells
Hajnická et al., Planta Med 2002 : The effect of the crude extract and of two alkaloid fractions prepared from Mahonia aquifolium on interleukin-8 (IL-8) production in the lipopolysaccharide (LPS) stimulated human monocytic cell line THP-1 was studied
Aikawa et al., Inflamm Res 2002 (Leukemia, Monocytic, Acute) : These results suggest that the inhibitory effect of T-614 on the production of TNF-alpha, IL-6 and IL-8 in LPS stimulated THP-1 cells may involve transcriptional regulation through suppression of NF-kappaB activation without interfering with IkappaBalpha degradation
Sugimoto et al., Drugs Exp Clin Res 2002 : KE-758 had no effect on p75 and p55 soluble TNF receptor production in IFN-gamma and LPS stimulated THP-1 cells
Jefferies et al., J Biol Chem 2003 : Stimulation of the human monocytic cell line THP-1 with LPS resulted in an increase in the level of tyrosine phosphorylation of Btk ( indicative of activation )
Tanaka et al., J Pharmacobiodyn 1992 (Leukemia) : Northern blotting analysis using LPS stimulated THP-1 cells indicated that the inhibitory effect of T-614 on IL-1 beta production is caused by the suppression of IL-1 beta mRNA expression
Carman et al., Biochem Biophys Res Commun 2004 : Full length Nup214 co-precipitated with TTP from resting and LPS stimulated THP-1 cells, indicating that this interaction occurred in intact cells
González et al., Br J Pharmacol 2004 (Colitis...) : Diosmectite had a dose dependent inhibitory effect on IL-1beta production by LPS stimulated THP-1 cells
Zhou et al., Acta Pharmacol Sin 2004 (Leukemia, Myeloid) : alpha-Pinene pretreatment decreased the NF-kappa B/p65 nuclear translocation in LPS stimulated THP-1 cells, and this effect was dose dependent, but there was no reaction in LPS unstimulated THP-1 cells ... alpha-Pinene pretreatment increased I kappa B alpha protein level in cytoplasm, compared with that in LPS stimulated THP-1 cells
Ma et al., J Leukoc Biol 2004 : Here, we demonstrate in lipopolysaccharide (LPS) stimulated human THP-1 cells and monocytes that NO ( .- ) regulates interleukin (IL)-8 and tumor necrosis factor alpha (TNF-alpha) by distinct mechanisms
Boonkaewwan et al., J Agric Food Chem 2006 : This study suggested that stevioside attenuates synthesis of inflammatory mediators in LPS stimulated THP-1 cells by interfering with the IKKbeta and NF-kappaB signaling pathway, and stevioside induced TNF-alpha secretion is partially mediated through TLR4
Fujigaki et al., J Biochem 2006 : An electrophoretic mobility shift assay using STAT1alpha and IRF-1 consensus oligonucleotide probes showed no STAT1alpha or IRF-1 binding activities in LPS stimulated THP-1 cells
Birrell et al., J Pharmacol Exp Ther 2006 (Inflammation...) : In lipopolysaccharide (LPS) stimulated THP-1 cells and primary human lung tissue macrophages, the MMP inhibitor had no significant effect on the release of tumor necrosis factor-alpha, interleukin (IL)-8, IL-1 beta, growth regulated oncogene-alpha, macrophage inflammatory protein-1 alpha, or IL-6 whereas dexamethasone has a significant impact on all cytokines from both cell types
Stephenson et al., J Immunol 2006 : With respect to inflammation, activated protein C inhibited the production of TNF, IL-1beta, IL-6, and IL-8 by LPS stimulated THP-1 cells
Allen-Hall et al., J Ethnopharmacol 2007 (MAP Kinase Signaling System) : We also showed that treatment of LPS stimulated THP-1 cells with Uncaria tomentosa extracts blocked ERK1/2 and MEK1/2 phosphorylation in a dose dependent manner
Foster et al., J Leukoc Biol 2007 : After 24 h, P. gingivalis LPS stimulated monocytic THP1 cells to differentiate into macrophages, which predominantly expressed TLR2, and E. coli LPS stimulated THP1 differentiation to predominantly TLR4 expressing macrophages
van Zoelen et al., Thromb Haemost 2006 : EP dose-dependently inhibited the production of tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta by lipopolysaccharide (LPS) stimulated THP-1 cells at mRNA and protein level, thereby confirming its anti-inflammatory properties in this in-vitro system ... In addition, EP dose-dependently attenuated the increases in TF mRNA levels, TF-protein-surface expression and cell-surface associated TF activity in LPS stimulated THP-1 cells
Yu et al., Fish Shellfish Immunol 2007 : LPS induced TNF-alpha factor (LITAF) is a novel transcriptional factor that was first discovered in LPS stimulated human macrophage cell line THP-1
Zhou et al., Acta Pharmacol Sin 2007 : 1,8-Cineol pretreatment decreased the expression of Egr-1 in both the nuclei and whole cell of the LPS stimulated THP-1 cells, and this effect was concentration dependent, but there was no reaction on the expression of NF-kappaB in the nuclei protein in the LPS stimulated THP-1 cells
Kim et al., J Ethnopharmacol 2007 (Cerebral Infarction) : However, pretreatment with Sopung markedly inhibited the secretion of TNF-alpha and IL-6, but not IL-1beta, in lipopolysaccharide (LPS) stimulated THP-1/M cells and PBMCs treated with LPS and phytohemagglutinin ( PHA )
Iwata et al., J Endotoxin Res 2007 (Inflammation) : Therefore, we examined cytokine productivity and associated signal transduction molecules in LPS stimulated the monocytic cell line THP-1 , under conditions of hyperglycemia
Kuijk et al., Mol Immunol 2008 : Our study revealed that LPS stimulated THP-1 cells treated with simvastatin had an increased caspase-1 mediated processing of proIL-1beta
Im et al., Toxicol Lett 2008 : Meanwhile, treatment with actinomycin D facilitated the Trp-P-1 induced down-regulation of IL-8 expression in LPS stimulated THP-1 cells, implying that the inhibition might be due to a decrease in the stability of IL-8 mRNA rather than an attenuation of IL-8 transcription
Caffieri et al., J Pharm Biomed Anal 2008 (Hemolysis...) : Indeed, experiments on LPS stimulated THP-1 cells demonstrated the loss of anti-inflammatory activity when HCA was UVB photodegraded
Chen et al., Nan Fang Yi Ke Da Xue Xue Bao 2008 : The culture supernatant of the LPS stimulated THP-1 cells was collected and added into LO2 cell culture, and after incubation, the cells were lysed to extract the proteins for SDS-PAGE and Western blotting ... Treatment of the LO2 cells with the culture supernatant of LPS stimulated THP-1 cells resulted in positivity of CRP in the cell lysate and the culture supernatant ... CRP can not be up-regulated directly by LPS treatment in LO2 cells, but can be induced by certain cytokines ( IL-6 ) secreted from LPS stimulated THP-1 cells
Chen et al., J Gastroenterol Hepatol 2009 (Body Weight...) : The capacity of muscovite to adsorb cytokines in vitro was determined by the changes in the amount of TNF-alpha, IL-1beta secreted by lipopolysaccharide (LPS) stimulated THP-1 cells and IL-8 secreted by LPS stimulated HT-29 cells
Brackett et al., J Biomed Mater Res B Appl Biomater 2009 (Pulpitis) : When THP1 were activated by LPS after exposure to the sealers, differential suppression of TNFalpha, IL1beta, and IL6 secretion was observed for two of the five sealers tested
Ikegaya et al., J Chemother 2009 : We investigated in vitro the effect of azithromycin on tumor necrosis factor alpha (TNF-alpha) production in lipopolysaccharide (LPS) stimulated THP-1 cells, a human monocytic cell line, and compared the results with those for other macrolides, minocycline and ofloxacin
Wang et al., Cytokine 2010 : ApoA-I significantly decreased sL-selectin, sICAM-1 and sVCAM-1 release ( P < 0.01, P < 0.01, P < 0.05, respectively ) from LPS stimulated THP-1 cells
Xue et al., Toxicol In Vitro 2010 (Inflammation) : HUVECs treated with supernatants of LPS stimulated THP1 cells were used as the positive controls
Ricciotti et al., J Immunol 2010 : We compared the effects of NCX 4040 with those of NCX 4016 or aspirin on IkappaB-alpha stabilization and proteasome activity in the LPS stimulated human monocytic cell line THP1
Kuo et al., J Food Sci 2010 (Asthma...) : 1alpha,25- ( OH ) ( 2 ) D ( 3 ) could significantly suppress TNF-alpha and IP-10 expression in LPS stimulated THP-1 and human primary monocytes
Campbell et al., Blood 2010 (Venous Thrombosis) : We have adapted the corn-trypsin inhibitor whole-blood model to include EA.hy926 as an endothelium surrogate to evaluate the vascular modulation of blood coagulation initiated by relipidated recombinant tissue factor ( rTf ) and a cellular Tf surrogate, lipopolysaccharide (LPS) stimulated THP1 cells ( LPS-THP-1 )
Yamazaki et al., Chem Pharm Bull (Tokyo) 2011 : Since less attention has been paid to alkaloids in the diets than to polyphenols in this regard, we aimed at investigating anti-inflammatory activity of herb derived alkaloids through suppression of TNF-a and NO production in lipopolysaccharide (LPS) stimulated mouse RAW264 and/or human THP-1 cells
Yan et al., PloS one 2012 (Disease Models, Animal...) : By adhesion and transwell migration assays, we found that Gu-4 treatment inhibited the adhesion and transendothelial migration of LPS stimulated THP-1 cells ... Western blot analyses further revealed that Gu-4 treatment markedly inhibited the activation of spleen tyrosine kinase in LPS stimulated THP-1 cells
Murakami et al., Naunyn Schmiedebergs Arch Pharmacol 2012 (MAP Kinase Signaling System) : Furthermore, IVIG inhibited TNF-a, IL-6, and HMGB1 production from LPS stimulated THP-1 cells treated with PMA
Huang et al., Am J Chin Med 2012 (Inflammation) : Our results showed that LEO increased HSP70 expression in LPS stimulated THP-1 cells, suggesting that the LEO inhibited LPS induced inflammatory effect might be associated with the expression of HSP70
den Hartigh et al., PloS one 2012 : We showed that apoE3 complexed to phospholipid vesicles attenuates LPS induced THP-1 monocyte cytokine expression, while apoE4 increases expression
Ryu et al., Curr Alzheimer Res 2013 (Alzheimer Disease...) : In vitro, angiostatin significantly attenuated secretion of the pro-angiogenic agent, vascular endothelial growth factor ( VEGF ) in lipopolysaccharide (LPS) stimulated THP-1 cells
Kamata et al., Clin Exp Dermatol 2013 (Psoriasis) : CsA significantly reduced both IL-12/23p40 and IL-23 production by LPS stimulated THP-1 cells, but not in LPS stimulated macrophage-like differentiated THP-1 cells
Lind et al., Marine drugs 2013 : Barettin was also able to inhibit the secretion of the inflammatory cytokines IL-1ß and TNFa from LPS stimulated THP-1 cells
Kovacs et al., J Leukoc Biol 1987 : THP-1 produced IL-1 upon stimulation with lipopolysaccharide (LPS) , whereas U937.1 did not
Biondillo et al., Am J Physiol 1994 : These studies demonstrate the ability of interferon-gamma (IFN-gamma) to significantly enhance IL-6 mRNA and protein production in LPS stimulated monocytes and THP-1 cells
Shattock et al., J Virol 1993 : Adherence of lipopolysaccharide (LPS) stimulated THP-1 cells to either tissue culture plastic or endothelial cells was crucial for enhanced HIV-1 transcription as measured by LTR-CAT expression
Weinstein et al., J Immunol 1993 : We have now demonstrated that LPS also increases protein tyrosine phosphorylation in human monocyte derived macrophages and in the human monocytic cell line, THP-1
Natarajan et al., Biochim Biophys Acta 1994 : LPS mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine ( 2 microM ) and by protein kinase C ( PKC ) down-regulation with 12-O-tetradecanoylphorbol 13-acetate ( TPA ) suggesting a role for PKC
Tang et al., Biochemistry 1996 : In intact cell systems ( LPS induced THP-1 and TNF cDNA transfected COS-7 ), a trimer of pro-TNF was detected after chemical cross linking based on its molecular weight in Western blotting analysis
Metcalf et al., Am J Physiol 1996 : E1A 13S also increased endogenous TNF mRNA production in LPS stimulated THP-1 cells
Haeffner et al., J Immunol 1997 : Inhibition of TNF-alpha secretion by LPS stimulated THP-1-hGH cells was associated with a decrease in nuclear translocation of nuclear factor-kappaB
Su et al., Biotechniques 1997 : Furthermore, it has been used successfully for the investigation of differential mRNA expression levels of tumor necrosis factor alpha (TNF-alpha) and Interleukin-1 beta (IL-1 beta) in lipopolysaccharide (LPS) stimulated THP-1 cells ( a human monocytic cell line ) and the identification of specific IL-1 beta transcriptional inhibitors
Oquendo et al., Res Immunol 1997 (Lymphoma, B-Cell) : When PMA- or PMA+LPS stimulated THP-1 cells were exposed to HBV, TNF alpha protein and mRNA significantly decreased ( > 50 % )
Pugin et al., Infect Immun 1998 : LPS induced cell activation of THP1-wtCD14 and of THP1-tmCD14 ( protein tyrosine kinase phosphorylation, NF-kappaB activation, and cytokine production ) in a very similar manner