Gene interactions and pathways from curated databases and text-mining

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EPOR — PRL

Pathways - manually collected, often from reviews:

  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: CSF3/EPO/IFNA7/CSH1/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNB1/IL2/OSM/PRL/IFNA7/IFNA7 → IL3RA/IL2RB/IFNAR1/OSMR/PRLR/IL7R/IL6R/CSF3R/IL2RA/EPOR/IL4R/IL2RG/IFNAR2/GHR (activation)

Text-mined interactions from Literome

Um et al., J Biol Chem 2006 (Neuroblastoma) : To explore the role of different signaling pathways in Epo mediated antiapoptotic effects in differentiated human neuroblastoma SH-SY5Y cells, we employed a prolactin receptor (PrlR)/erythropoietin receptor (EpoR) chimera system, in which binding of prolactin (Prl) to the extracellular domain activates EpoR signaling in the cytosol
Dusanter-Fourt et al., EMBO J 1994 : PRL induced rapid and transient tyrosine phosphorylation of both the PRL-R and the PRL/EPO-R in BAF-3 transfectants