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IGF1 — SETD2
Text-mined interactions from Literome
Treins et al., Mol Endocrinol 2005
:
We show that
IGF-I stimulates HIF-1alpha accumulation, HIF-1alpha nuclear translocation, and
HIF-1 activity by regulation of HIF-1alpha expression through a posttranscriptional mechanism ... In addition, we demonstrate that
IGF-I stimulates
HIF-1 activity through phosphatidylinositol-3-kinase/ mammalian target of rapamycin and MAPK dependent signaling pathways leading to VEGF ( vascular endothelial growth factor ) mRNA expression
Dimova et al., Thromb Haemost 2005
(MAP Kinase Signaling System...) :
Furthermore,
IGF-1 enhanced HIF-1alpha protein levels and
HIF-1 DNA binding to each HRE, E4 and E5 as shown by EMSA
Sutton et al., Oncogene 2007
:
Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of
HIF-1 in
response to hypoxia and
IGF-1 ... Interestingly however, the highly selective MEK1/2 inhibitor PD184352 did not inhibit HIF-1 activity or vascular endothelial growth factor ( VEGF ) induced in response to hypoxia but blocked HIF-1alpha protein and
HIF-1 activity
induced by
IGF-1 stimulation without affecting HIF-1alpha mRNA levels ... Taken together, our data suggest that although ERK1/2 signalling is important for HIF-1alpha induction and
HIF-1 activity in
response to
IGF-1 , it is dispensable for the induction of HIF-1alpha and activation of HIF-1 in response to hypoxia
Thomas et al., Prostate 2009
(Prostatic Neoplasms) :
Furthermore,
HIF-1alpha suppression
attenuated the serum deprivation mediated increase in Akt and
IGF-IR activation
Gariboldi et al., Biochem Pharmacol 2010
(Glioblastoma) :
Our results show that exogenous
IGF-I causes IGF1R and STAT3 activation, and
increases HIF1alpha protein levels and
HIF1 trascriptional activity, inducing VEGF release ; a similar response, mediated by IGF-II release, is observed following HIF1alpha stabilization
Sinha et al., Cell Signal 2011
(Glioblastoma...) :
As HIF-1a links inflammatory and oncogenic pathways in GBM, we investigated whether
IGF-1 affects
HIF-1a? to regulate inflammatory response in glioma cells under normoxia ... Interestingly, while synthetic CpG containing oligodeoxynucleotide TLR9 agonist ( CpG DNA ) decreased
IGF-1 mediated increase in
HIF-1a activity, siRNA mediated knockdown of HIF-1a decreased TLR9 levels
Yu et al., Brain Res 2012
:
Using echinomycin, a HIF-1 inhibitor, and HIF-1a siRNA, we demonstrated
IGF-1 induced GLUT3 expression through
HIF-1a in neuronal PC12 cells ... Moreover,
IGF-1 stimulated
HIF-1a and GLUT3 protein expression through phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR dependent pathways ... Moreover,
IGF-1 stimulated
HIF-1a and GLUT3 protein expression through phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR dependent pathways
Sartori-Cintra et al., Clinics (Sao Paulo) 2012
(Osteoarthritis) :
Regulation of
hypoxia-inducible factor-1a (HIF-1a) expression by interleukin-1ß (IL-1 ß),
insulin-like growth factors I (IGF-I) and II ( IGF-II ) in human osteoarthritic chondrocytes ... IL-1ß upregulated the levels of HIF-1a protein post-transcriptionally, whereas
IGF-I increased
HIF-1a at the transcript level ... In contrast,
IGF-II did not
affect the protein or gene expression levels of
HIF-1a
Piecewicz et al., PloS one 2012
:
We confirmed that
IGF-IGFR1 signaling
stabilizes HIF1a and leads to up-regulation of VEGF during vasculogenesis in embryoid bodies
Yoon et al., J Assist Reprod Genet 2013
:
Effects of oxygen tension and
IGF-I on
HIF-1a protein expression in mouse blastocysts
Hinkel et al., Curr Vasc Pharmacol 2013
(Constriction, Pathologic...) :
Hif-1a , a master regulator of ischemia-responsive gene induction,
controls pro-angiogenic gene expression of VEGF-A, flt-1,
IGF-1 and erythropoietin, rendering its overexpression an attractive tool for therapeutic neovascularization
Dal Monte et al., Exp Eye Res 2013
(Disease Models, Animal...) :
Propranolol ophthalmic solutions reduced VEGF and
IGF-1 up-regulation in response to hypoxia and drastically
inhibited HIF-1a accumulation and STAT3 phosphorylation
Kurabayashi et al., PloS one 2013
:
Because the effect of IGF-I on
HIF-1a protein synthesis is
mediated by
IGF-IR , our results indicated that VHL inactivation accelerated hepatic glucose storage through the upregulation of IGF-IR and GLUT1 and that IGF-IR was a key regulator in VHL-deficient hepatocytes ... Because the
effect of
IGF-I on
HIF-1a protein synthesis is mediated by IGF-IR, our results indicated that VHL inactivation accelerated hepatic glucose storage through the upregulation of IGF-IR and GLUT1 and that IGF-IR was a key regulator in VHL-deficient hepatocytes