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FOXO1 — IL1A
Text-mined interactions from Literome
Su et al., Diabetes 2009
(Diabetes Mellitus, Type 2...) :
FoxO1 selectively
promoted IL-1ß production in cultured macrophages ... Mutations of the FoxO1 binding site within the IL-1ß promoter abolished
FoxO1 induction of
IL-1ß expression
Dobierzewska et al., J Biol Chem 2012
:
The
IL-1ß effects on
FoxO1 are counteracted, however, by the silencing or inhibition of neutral sphingomyelinase 2 (nSMase-2) using shRNAi, scyphostatin, or GW4869, as well as by the pharmacological inhibition of JNK and ERK ... In conclusion, we propose that
IL-1ß regulates
FoxO1 activity through a novel nSMase-2 dependent pathway